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IRCT20180804040688N1 IRCT 2018-08-15 Gonabad University of Medical Sciences The effect of vitamin E and C on risk factors of coronary artery disease (CAD) مطالعه بیماری های عروق کرونر The effect of vitamin E and C supplements on risk factors of coronary artery disease (CAD) in patients with coronary heart disease 2018-09-23 anticipated 88 Complete https://irct.ir/trial/33137 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Factorial, Purpose: Treatment, Randomization description: Randomization method: permutation block Random unit: Individual Randomization Tool: Random Numbers. 3 Coronary artery disease (CAD). Intervention 1: Vitamin E Group: This group only consumes vitamin E supplement of 600 mg daily for 10 weeks. Intervention 2: Vitamin C Group: This group only consumes vitamin C supplement of 1000 mg daily for 10 weeks. Intervention 3: Combination Group: This group consumes vitamin E of 600 mg and vitamin C of 1000 mg supplements daily for 10 weeks. Intervention 4: Control group: This group will not receive any supplement. Yes - There is a plan to make this available What will be shared: Potential data will be shared after unidentifiable individuals. When: Get started 8 months after the publication of results To whom: The researcher on academic institutions Conditions: The information should not be changed. Where to obtain: E-mail Sajjad Rezaei: sajadrezaeistusurgical009@gmail.com E-mail Samane Najafi: s.najafi2012@yahoo.com How to obtain: The E-mail to the given address and provide sufficient and acceptable information. Information will be given if data is acceptable. Comments:
public Sajjad Rezaei
No. 4, 10 Golriz Ave., 10 sarakhs Ave., Mashhad, Khorasan Razavi, Iran.
Mashhad Iran (Islamic Republic of) 9167911713 +98 51 3366 4228 sajadrezaeistusurgical009@gmail.com Gonabad University of Medical Sciences scientific Samane Najafi
School of nursing, Gonabad University of Medical Sciences, next to the Asian Road, Gonabad, Khorasan Razavi, Iran.
Gonabad Iran (Islamic Republic of) 91673911713 +98 51 5722 5027 s.najafi2012@yahoo.com Gonabad University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Inclination to participate in research Certification of physician to receive vitamins E and C Age 18 to 50 years old Acceptable listening, speaking and consciousness to answer the questions Waist circumference is more than 102 cm in men and more than 88 cm in women Fasting triglyceride equal to or greater than 150 mg/dl HDL less than 40 mg/dl Systolic blood pressure equal to or greater than 135 mm Hg Fasting glucose is greater than or equal to 110 mg/dl 18 years 50 years Both Not pregnant Do Not taking corticosteroids and contraceptives Lack of underlying diseases (such as kidney and liver failure, thyroid dysfunction, malignancy, mental, autoimmune and infectious diseases) Lack of specific medical conditions requires as a change in diet and exercise program Lack of insulin treatment The need for surgery during the study Cancellation request of the patient Incidence of unwanted side effects Irregular consumption of supplements I25.1 Atherosclerotic heart disease of native coronary artery Treatment - Drugs Treatment - Drugs Treatment - Drugs Other Vitamin E Group: This group only consumes vitamin E supplement of 600 mg daily for 10 weeks. Vitamin C Group: This group only consumes vitamin C supplement of 1000 mg daily for 10 weeks. Combination Group: This group consumes vitamin E of 600 mg and vitamin C of 1000 mg supplements daily for 10 weeks. Control group: This group will not receive any supplement. Systolic and diastolic blood pressure. Timepoint: Before and after the intervention. Method of measurement: Mercury sphygmomanometer. Lipid profiles. Timepoint: Before and after the intervention. Method of measurement: Laboratory instruments. Fasting blood sugar. Timepoint: Before and after the intervention. Method of measurement: Laboratory instruments. Body mass index (BMI). Timepoint: Before and after the intervention. Method of measurement: Weight (kilograms) / square height (meter). C-reactive protein (CRP). Timepoint: Before and after the intervention. Method of measurement: Laboratory instruments. Gonabad University of Medical Sciences Approved 2018-08-04 Gonabad University of Medical Sciences Research Deputy in Gonabad University of Medical Sciences, next to the Asian Road, Gonabad, Khorasan Razavi, Iran. Gonabad Razavi Khorasan Iran (Islamic Republic of)