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IRCT20120527009878N2 IRCT 2018-08-18 Tabriz University of Medical Sciences Evaluation the effect of minocycline in reducing postoperative pain Effect of minocycline on postoperative pain after lumbar discectomy 2018-03-21 anticipated 80 Complete https://irct.ir/trial/33252 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: Selecting groups is completely random and will be done after matching. Randomization of patients will be done by file number using www.random.org site. On this site, the Gaussian rendumization method was used with normal distribution, Blinding description: The main intervention medication and placebo are both ordered by the HEXAL Company and will be completely alike. 3 Lumbar disc discectomy. Intervention 1: Intervention group: Minocycline tablet (50 mg) in 4 dose: one tablet one day before surgery, one tablet before surgery procedure, one tablet after surgery procedure, one tablet one day after surgery. Intervention 2: Control group: Placebo tablet, (50 mg) in 4 dose: one tablet one day before surgery, one tablet before surgery procedure, one tablet after surgery procedure, one tablet one day after surgery. Yes - There is a plan to make this available What will be shared: Data encoded and unidentified data can be provided to other researchers. When: After the paper is published, the project is accessible. To whom: Individuals with organizational characteristics of the Academic Research Center Conditions: Data can only be used for statistical analysis purposes with new studies Where to obtain: To receive the data, you can refer to the responsible respondent. How to obtain: After coordination with the responsible person and approval of the research committee and the vice chancellor of the research center are available. Comments:
public Dr. Firoz Salehpoor
Neurosurgery ward, Emam Reza Hospital, Gholghasht Street, Azadi Street, Tabriz
Tabriz Iran (Islamic Republic of) 5166614756 +98 41 1334 0830 salehpourf@tbzmed.ac.ir Tabriz University of Medical Sciences scientific Dr. Firoz Salehpoor
Neurosurgery ward, Emam Reza Hospital, Gholghasht Street, Azadi Street, Tabriz
Tabriz Iran (Islamic Republic of) 5166614756 +98 41 1334 0830 salehpourf@tbzmed.ac.ir Tabriz University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Age between 18 and 70 years Weight between 60 and 80 kilograms Conformity of clinical signs and symptoms with MRI findings ُSigned informed consent 18 years 70 years Both Previous lumbar surgery History of alcohol or drug addiction Morphine complications during examination Pregnancy Breast feeding Decisions to increase the extent of surgery Use of analgesics over the last 24 hours Full improvement of neuropathic pain after surgery The presence of aphasia and visual impairment or illiteracy that prevents communication with the patient. Lumbar canal stenosis, Listeriosis, Infection, Spinal cord or bone tumors M51.9 Intervertebral disc disorder, unspecified Treatment - Surgery Placebo Intervention group: Minocycline tablet (50 mg) in 4 dose: one tablet one day before surgery, one tablet before surgery procedure, one tablet after surgery procedure, one tablet one day after surgery. Control group: Placebo tablet, (50 mg) in 4 dose: one tablet one day before surgery, one tablet before surgery procedure, one tablet after surgery procedure, one tablet one day after surgery. Lumbar pain after surgery. Timepoint: After surgery in recovery, one day after surgery. Method of measurement: Visual Analogue Scale. Tabriz University of Medical Sciences Approved 2018-08-06 Tabriz University of Medical Science Tabriz University of Medical Science , Gholghasht street , Azadi street, Tabriz Tabriz East Azarbaijan Iran (Islamic Republic of)