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IRCT20140310016917N6 IRCT 2018-10-16 Rasht University of Medical Sciences The effects of local tranexamic acid on dacryocystorhinostomy hemorrhage The effects of local tranexamic acid on reducing of intra and post external dacryocystorhinostomy hemorrhage in patients with primary acquired nasolacrimal duct abstruction 2018-09-06 anticipated 126 Complete https://irct.ir/trial/33506 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Quadruple random blocks using statistical software, Blinding description: Participant: the patient is unaware of the type of local drug combination. Clinical care: the person administering the drug is unaware of the presence of tranexamic acid. Evaluation of outcomes: the type of drug combination is not known and only measures the amount of bleeding. 3 Congenital and secondary stenosis and stricture of lacrimal duct. Intervention 1: Intervention group: 3.5ml Bupicaine 5%, 4ml Lidocain 2%, 0.1ml Aderenalin 1/100000,2.5ml Tranexamic Acid. Intervention 2: Control group: 3.5ml Bupicaine 5%, 4ml Lidocain 2%, 0.1ml Aderenalin 1/100000,Normal salin 0.05 ml/kg. Yes - There is a plan to make this available What will be shared: It will be published as a scientific article When: A year after the publication of the article To whom: Researchers working in academia and academia Conditions: There is no item Where to obtain: aliashraf@gums.ac.ir How to obtain: aliashraf@gums.ac.ir Comments:
public Ali Ashraf
Prastar street
Rasht Iran (Islamic Republic of) 41937-13194 +98 13 3332 2250 aliashraf@gums.ac.ir Rasht University of Medical Sciences scientific Ali Ashraf
Parastar street
Rasht Iran (Islamic Republic of) 41937-13194 +98 13 3332 2250 aliashraf@gums.ac.ir Rasht University of Medical Sciences Iran (Islamic Republic of) Patients with primary and acquired obstruction of the nasolacrimal duct undergo surgery for dacryosisturinostomy under local anesthesia 50 years no limit Both Coagulation disorders Age less than 50 years Surgery with general anesthesia Allergic reaction to lidocaine or tranexamic acid Uncontrolled hypertension History of anticoagulation History of thromboembolic disease and thrombophilia Hemoglobin is less than 10 Q10.5 Congenital stenosis and stricture of lacrimal duct Treatment - Drugs Treatment - Drugs Intervention group: 3.5ml Bupicaine 5%, 4ml Lidocain 2%, 0.1ml Aderenalin 1/100000,2.5ml Tranexamic Acid Control group: 3.5ml Bupicaine 5%, 4ml Lidocain 2%, 0.1ml Aderenalin 1/100000,Normal salin 0.05 ml/kg Reduced bleeding during surgery. Timepoint: During and after the surgery. Method of measurement: Suctioned blood volume and quality of the surgical field surgeon. Rasht University of Medical Sciences Approved 2018-09-22 Ethics committee of Guilan university of Medical Sciences Namjoo street Rasht Guilan Iran (Islamic Republic of)