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IRCT20100520003979N8 IRCT 2018-09-22 Ahvaz University of Medical Sciences Effecting the combination of memantine and methylphenidate in children affected by attention deficit hyperactivity disorder Comparison of the effects of different doses of memantine in combination with methylphenidate in children affected by attention deficit hyperactivity disorder 2018-09-23 anticipated 69 Complete https://irct.ir/trial/33530 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Based on the method of the permutation 4blocks, individuals are randomly divided into two groups, Blinding description: In this study, the patient, nurse, and evaluator did not know how much memantine was taken by each patient. each group did not have any information that another group exists and receive a different dose. Because medicines are packaged in the form of one and two, and delivered to the patient. 2-3 attention deficit hyperactivity disorder. Intervention 1: Intervention group 1: In this group, memantine is given at a dose of 0.1 to 0.25 mg / kg. In this group, with a minimum dose of memantine 0.1, it starts with ritalin, and gradually we increase and maximize the dose within two weeks. Ritalin is given at a fixed dose. In the first week, one fourth of the pill is taken twice daily, the second week, the second one, twice a day, the third week, three quarters of the pill twice daily, and the fourth week, once a pill twice a day, and until the end of the study, the dose remains constant. Intervention 2: Intervention group 2: In this group, memantine is given at a dose of 0.25 to 0.50mg / kg. In this group, with a minimum dose of memantine 0.25, it starts with ritalin, and gradually we increase and maximize the dose within two weeks. Ritalin is given at a fixed dose. In the first week, one fourth of the pill is taken twice daily, the second week, the second one, twice a day, the third week, three quarters of the pill twice daily, and the fourth week, once a pill twice a day, and until the end of the study, the dose remains constant.This drug is prescribed to patients in the form of placebo with the same form, color, smell and taste. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is "No more information"
public Forough Riahi
Golestan hospital,Golestan Blvd,Ahvaz
Ahvaz Iran (Islamic Republic of) 6135715794 +98 61 3374 3038 Riahi13@gmail.com Ahvaz University of Medical Sciences scientific Maryam Enayatollahi
Golestan hospital,Golestan Blvd,Ahvaz
Ahvaz Iran (Islamic Republic of) 6135715794 +98 61 3374 3038 Mary208067@gmail.com Ahvaz University of Medical Sciences Iran (Islamic Republic of) Age of children aged 6 to 12 years Having diagnostic criteria based on IV-IRDSM and Conners test 6 years 12 years Both Another serious psychiatric disorder, such as schizophrenia, bipolar disorder A history of seizure and medical conditions such as cardiovascular problems and diabetes History of allergy for Memantine Failure to respond to Memantine Severe ritalin complications F90.0 Attention-deficit hyperactivity disorder, predominantly inattentive type Treatment - Drugs Treatment - Drugs Intervention group 1: In this group, memantine is given at a dose of 0.1 to 0.25 mg / kg. In this group, with a minimum dose of memantine 0.1, it starts with ritalin, and gradually we increase and maximize the dose within two weeks. Ritalin is given at a fixed dose. In the first week, one fourth of the pill is taken twice daily, the second week, the second one, twice a day, the third week, three quarters of the pill twice daily, and the fourth week, once a pill twice a day, and until the end of the study, the dose remains constant. Intervention group 2: In this group, memantine is given at a dose of 0.25 to 0.50mg / kg. In this group, with a minimum dose of memantine 0.25, it starts with ritalin, and gradually we increase and maximize the dose within two weeks. Ritalin is given at a fixed dose. In the first week, one fourth of the pill is taken twice daily, the second week, the second one, twice a day, the third week, three quarters of the pill twice daily, and the fourth week, once a pill twice a day, and until the end of the study, the dose remains constant.This drug is prescribed to patients in the form of placebo with the same form, color, smell and taste. Attention Deficit Hyperactivity Disorder. Timepoint: Befor intervention- the end of second, fourth and sixth,eighth, tenth,twelfth weeks of the study. Method of measurement: The Conner's parent rating scale. Ahvaz University of Medical Sciences Approved 2017-05-20 Ethics committee of Ahvaz Jundishapur University of Medical Sciences Golestan Blvd, Ahvaz, Khoozestan Ahvaz Khouzestan Iran (Islamic Republic of)