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IRCT20171007036616N1 IRCT 2018-10-01 Abidi Pharma Comparison of the Effect of Omeprazole,Pantoprazole,Esomeprazole and Lansoprazole on the Patients with Gastroesophageal Reflux Disease Comparison of The effect of Omeprazole,Pantoprazole,Esomeprazole and Lansoprazole on the Symptoms in Patients with Gastroesophageal Reflux Disease 2018-01-21 anticipated 120 Complete https://irct.ir/trial/33541 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple: Patients were randomized in each of the four interventional groups by using Table of Random Digits. Patients who were excluded from the project for any reason were replaced by new patients. 4 Gastro-oesophageal Reflux Disease. Intervention 1: omeprazole 40mg daily(the pateint will consume two 20mg omeperazole capsules on fasting every morning for 8 weeks). Intervention 2: Pantoprazole 40mg daily(the pateint will consume one 40mg Pantoprazole capsule on fasting every morning for 8 weeks). Intervention 3: Esomeprazole 40mg daily(the pateint will consume one 40mg Esomeprazole capsule on fasting every morning for 8 weeks). Intervention 4: Lansoprazole 30mg daily(the pateint will consume one 30mg Lansoprazole capsule on fasting every morning for 8 weeks). Yes - There is a plan to make this available What will be shared: Questionnaire Informed consent form Outcomes When: 6 month after publishing To whom: Any researcher Conditions: Any Reseacher Where to obtain: Nima Arezoomandi,Email How to obtain: Email Comments:
public Nima Arezoomandi
Hakim Nezami
Isfahan Iran (Islamic Republic of) 8175887573 +98 316532021 qoghnus@gmail.com Esfahan University of Medical Sciences scientific Nima Arezoomandi
Hakim Nezami
Isfahan Iran (Islamic Republic of) 8175887573 +98 31 3653 2021 qoghnus@gmail.com Esfahan University of Medical Sciences Iran (Islamic Republic of) Patients with Gastroesophageal Reflux Disease with frequent symptoms(2 or more symptoms per week) no limit no limit Both Weight Loss History of cancer Odinophagia Dysphagia K21 Gastro-esophageal reflux disease Treatment - Drugs Treatment - Drugs Treatment - Drugs Treatment - Drugs omeprazole 40mg daily(the pateint will consume two 20mg omeperazole capsules on fasting every morning for 8 weeks) Pantoprazole 40mg daily(the pateint will consume one 40mg Pantoprazole capsule on fasting every morning for 8 weeks) Esomeprazole 40mg daily(the pateint will consume one 40mg Esomeprazole capsule on fasting every morning for 8 weeks) Lansoprazole 30mg daily(the pateint will consume one 30mg Lansoprazole capsule on fasting every morning for 8 weeks) Heart Burn. Timepoint: 0 , 2 , 4 , 8 weeks. Method of measurement: questionnaire. Acid Regurgitation. Timepoint: 0 , 2 , 4 , 8 weeks. Method of measurement: questionnaire. Total Satisfaction. Timepoint: 0,2,4,8 week. Method of measurement: Questionnaire. Abidi Pharma Approved 2017-05-30 Ethics committee of Isfahan Medical University Hezar Jarib Isfahan Isfehan Iran (Islamic Republic of)