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IRCT20180416039326N6 IRCT 2019-02-02 Esfahan University of Medical Sciences Effect of Thiopental Sodium - Midazolam on the hemodynamic response to the tracheal intubation and laryngeal mask insertion The effect of thiopental sodium-midazolam combination on hemodynamic response to tracheal intubation and laryngeal mask insertion 2018-12-29 anticipated 70 Complete https://irct.ir/trial/33713 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients who met the criteria for entering the study randomly using random numbers generated by the computer assign to group E (Tracheal intubation) and group L ( laryngeal mask-insertion), the Patient allocation was performed by an independent researcher, who was unaware of the study groups,  Sequence numbers in the sealed black envelope were kept in an inaccessible location, at the end of the study, these numbers list were available for data analysis, Blinding description: In this study, the patient will not be aware of the airway management and the information will be obtained single blind. 2 Hemodynamic response. Intervention 1: First intervention group: After receiving 5 ml / kg of ringer lactate and pre-oxygenation for patients, the same anesthetic induction was performed including Fentanyl 2mcg / kg, Thiopental sodium 2.5 mg / kg, Midazolam 0.1 mg/kg and Atracurium 0.5 mg / kg, and the patients underwent mechanical ventilation by mask for three minutes. Then the airway is protected by ETT and the patient is attached to the anesthetic machine and is mechanically ventilated and maintained anesthetized with iso-fluorine 0.8-1.2 Mac, with oxygen and N2O of 50%. Intervention 2: First intervention group: After receiving 5 ml / kg of ringer lactate and pre-oxygenation for patients, the same anesthetic induction was performed including Fentanyl 2mcg / kg, Thiopental sodium 2.5 mg / kg, Midazolam 0.1 mg/kg and Atracurium 0.5 mg / kg, and the patients underwent mechanical ventilation by mask for three minutes. Then the airway is protected by LMA and the patient is attached to the anesthetic machine and is mechanically ventilated and maintained anesthetized with iso-fluorine 0.8-1.2 Mac, with oxygen and N2O of 50%. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information
public Hamidreza Shetabi
Feiz Hospital, Modarres St
Isfahan Iran (Islamic Republic of) ۷۳۴۶۱-۸۱۷۶۴ +98 31 3668 8138 Hamidshetabi@med.mui.ac.ir Esfahan University of Medical Sciences scientific Hamidreza Shetabi
Feiz Hospital, Modarres St
Isfahan Iran (Islamic Republic of) 8176473461 +98 31 3445 2034 hamidshetabi@med.mui.ac.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) Patients undergoing elective short-term surgery less than two hours Age of 35 to 75 years and ASA I-II Informed consent to Participate in the Study 35 years 75 years Both Obese patients Pregnant women Diabetic patients COPD patients Cardiovascular patients predict difficult airway management History of allergy to used anesthetic drugs T88.5 Other complications of anaesthesia Treatment - Drugs Treatment - Drugs First intervention group: After receiving 5 ml / kg of ringer lactate and pre-oxygenation for patients, the same anesthetic induction was performed including Fentanyl 2mcg / kg, Thiopental sodium 2.5 mg / kg, Midazolam 0.1 mg/kg and Atracurium 0.5 mg / kg, and the patients underwent mechanical ventilation by mask for three minutes. Then the airway is protected by ETT and the patient is attached to the anesthetic machine and is mechanically ventilated and maintained anesthetized with iso-fluorine 0.8-1.2 Mac, with oxygen and N2O of 50%. First intervention group: After receiving 5 ml / kg of ringer lactate and pre-oxygenation for patients, the same anesthetic induction was performed including Fentanyl 2mcg / kg, Thiopental sodium 2.5 mg / kg, Midazolam 0.1 mg/kg and Atracurium 0.5 mg / kg, and the patients underwent mechanical ventilation by mask for three minutes. Then the airway is protected by LMA and the patient is attached to the anesthetic machine and is mechanically ventilated and maintained anesthetized with iso-fluorine 0.8-1.2 Mac, with oxygen and N2O of 50%. Heart rate. Timepoint: Basic time, minutes 1 and 3 after induction and minutes 1, 3, 5 and 10 after intubation. Method of measurement: Electrocardiogram (EKG). Blood pressure. Timepoint: Basic time, minutes 1 and 3 after induction and minutes 1, 3, 5 and 10 after intubation. Method of measurement: Pressure gauge. Mean arterial pressure. Timepoint: Basic time, minutes 1 and 3 after induction and minutes 1, 3, 5 and 10 after intubation. Method of measurement: Pressure gauge. Oxygen saturation percentage. Timepoint: Basic time, minutes 1 and 3 after induction and minutes 1, 3, 5 and 10 after intubation. Method of measurement: Pulse oximetry. Esfahan University of Medical Sciences Approved 2018-12-29 Ethics Committee of Isfahan University of Medical Sciences Isfahan University of medical sciences, Hezar Jarib Street Isfahan Isfehan Iran (Islamic Republic of)