]>
IRCT20151222025649N6 IRCT 2018-10-20 Kermanshah University of Medical Sciences Evaluation the effectiveness pomegranate peel extract in treatment of gingival inflammation Evaluation the effectiveness of oral gel containing pomegranate peel extract in treatment of periodontitis 2019-01-21 anticipated 32 Complete https://irct.ir/trial/34172 interventional Randomization: N/A, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Blinding description: Drugs with A and B are named by the drug manufacturer, so that until the end of the study, she khows the pomegranate gel content or placebo for each tube A and B; In this way researcher and statistical analysor will be blind. The patient have No information about the drug content will be placed on the study sites. 2-3 Moderate to severe chronic periodontitis. Intervention 1: Intervention group: The pomegranate peel extract gel in a periodontal pocket in a selected dental quadrant. After scalling all of the teeth with a piezoelectroscopic device in a pre-selected pocket, the pomegranate gel is injected and the area is coverd with coe-pack .the paitent asked to observe their oral health during the course of the study, but refrain from using dental floss and mouthwash in the studied area. Pomegranate and placebo gels produced in the pharmacy of Kermanshah University of Medical Sciences and they are absorbed by periodontal tissues after injection in periodontal pockets.The patient will be monitored for up to three months. The drug has polyphenol compounds such as gallic acid and is present at concentrations 15% and only 3-5ml in a periodontal envelope is injected. Intervention 2: Control group: The placebo in the periodontal pocket of another dental quadrant. This drug is similar to the pomegranate gel without any polyphenols.It is once and about 3-5 milligrams injected in the periodontal pocket of another quadrant. Treatments are same as the intervention group. Yes - There is a plan to make this available What will be shared: The total potential data after being unidentified is shared. When: Start the access, 6 months after printing the results To whom: All researchers can access the data Conditions: Using of data for use in other similar studies is warranted Where to obtain: School of Dentistry, Kermanshah University of Medical Sciences How to obtain: They can access information upon request from the Kermanshah University of Medical Sciences and receive confirmation. Comments:
public Masoome Eivazi
Opposite to the post office , Shariati Ave
Kermanshah Iran (Islamic Republic of) 6713954658 +98 83 3722 2400 m.eivazi@kums.ac.ir Kermanshah University of Medical Sciences scientific Masoome Eivazi
Opposite to the post office, Shariati Ave
Kermanshah Iran (Islamic Republic of) 6713954658 +98 83 3722 2400 m.eivazi@kums.ac.ir Kermanshah University of Medical Sciences Iran (Islamic Republic of) All patients with chronic periodontitis that are healthy in terms of systemicity No history of hypersensitivity no limit no limit Both Receive other treatments Tobacco and alcohol consumption Pregnant and nursing women Use of orthodontic appliance K05.3 Chronic periodontitis Treatment - Drugs Placebo Intervention group: The pomegranate peel extract gel in a periodontal pocket in a selected dental quadrant. After scalling all of the teeth with a piezoelectroscopic device in a pre-selected pocket, the pomegranate gel is injected and the area is coverd with coe-pack .the paitent asked to observe their oral health during the course of the study, but refrain from using dental floss and mouthwash in the studied area. Pomegranate and placebo gels produced in the pharmacy of Kermanshah University of Medical Sciences and they are absorbed by periodontal tissues after injection in periodontal pockets.The patient will be monitored for up to three months. The drug has polyphenol compounds such as gallic acid and is present at concentrations 15% and only 3-5ml in a periodontal envelope is injected. Control group: The placebo in the periodontal pocket of another dental quadrant. This drug is similar to the pomegranate gel without any polyphenols.It is once and about 3-5 milligrams injected in the periodontal pocket of another quadrant. Treatments are same as the intervention group. Pocket depth. Timepoint: Before intervention, one month after intervention, three months after intervention. Method of measurement: Measuring the distance of pocket base to the gingival with periodontal probe. Clinical attachment loss. Timepoint: Before intervention, one month after intervention, three months after intervention. Method of measurement: Measuring the distance of base of pocket from CEJ. Gingival index. Timepoint: Before intervention, one month after intervention, three months after intervention. Method of measurement: Determination gingival inflammatory conditions based on observation and comparison. Plaque index. Timepoint: Before intervention, one month after intervention, three months after intervention. Method of measurement: Colored surfaces of tooth by disclosing agent. Bleeding index. Timepoint: Before intervention, one month after intervention, three months after intervention. Method of measurement: Determination of inflammatory conditions and gingival hemorrhage during probingwith periodontal probe. Kermanshah University of Medical Sciences Approved 2018-10-01 Dentistry school of Kermanshah University of Medical Sciences Opposite of the Post office., Shariati Ave Kermanshah Kermanshah Iran (Islamic Republic of)