IRCT20170805035510N6 IRCT 2019-09-17 Tehran University of Medical Sciences Application of Tranexamic acid in prostatectomy surgery Assessing the efficacy of Tranexamic acid versus placebo in reducing fibrinolysis, blood loss, and transfusion requirements during open prostatectomy surgery 2019-09-23 anticipated 40 Complete https://irct.ir/trial/34307 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: Randomization is performed by employing the simple randomization method and random number table. Patients are allocated into two groups (20 patients in each group), Blinding description: The main researcher (anesthesiologist) and the patients are unaware of study allocation. A nurse anesthetist (who is not involved in the study) receives the randomization table in a sealed envelope and allocates patients to study group according to the table. Rotational thromboelastometry (ROTEM) analyses are performed by the anesthesiologist and obtained data are entered into Statistical Package for the Social Sciences (SPSS) software. All the clinical assessments, including blood loss estimation and adminstiring packed red blood cells are performed by the main researcher who is blinded to study groups. 2-3 Fibrinolysis and bleeding during open prostatectomy. Intervention 1: Intervention group: Patients receive tranexamic acid (10mg/kg) diluted in normal saline (100cc) over 30 minutes before initiation of surgery. Intervention 2: Control group: patients receive normal saline (100cc) over 30 minutes before initiation of surgery. No - There is not a plan to make this available Justification or reason for not sharing IPD is Considering the limited number of open prostatectomies which are performed in our hospital, there is a concern regarding our participants' privacy and whether were are able to maintain patients' anonymity.