IRCT20181006041253N1 IRCT 2019-01-08 Birjand University of Medical Sciences Nano-Tacrolimus and Cyclosporine effect in dry eye Comparative clinical evaluation of 0.05% Cyclosporine and 0.05% Nano -Tacrolimus eye drops for the treatment of dry eye 2018-12-22 anticipated 24 Complete https://irct.ir/trial/34353 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: We assigned patients a code from 1 to 12. Then we used a table of random numbers to select 12 numbers. For the 12 selected patients, the 0.05% Nano- Tacrolimus drug was used in the right eye and the 0.05% CsA drug was used in the left eye. On the other 12 patients, 0.05% Nano- Tacrolimus was used in the left eye and the 0.05% CsA drug was used in the right eye, Blinding description: In this study,the ophthalmologist who performs the examination and evaluation of the patients and the person who performs the data analysis is unaware of which drug is used. 3 Dry eye syndrome. Intervention 1: International group 1: 0.05% nano formulation Tacrolimus drop produced at the Abu Reyhan Pharmacy Company for one eye twice a day, One drop use in the lower conjunctiva for one month. Intervention 2: International group 2: Cyclosporine drop Sinadarou Company uses a drop in the lower conjunctiva for one month twice a day for another eye. No - There is not a plan to make this available Justification or reason for not sharing IPD is Because of the publication of the article