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IRCT20181009041286N1 IRCT 2019-01-17 Kashan University of Medical Sciences The effects of laxative drugs in the treatment of acute constipation in patients with acute stroke Comparison of response to two regimens of Lactolose and Bisacodyl in the treatment of acute constipation in patients with acute stroke 2017-12-22 anticipated 50 Complete https://irct.ir/trial/34398 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Selecting groups is completely random and will be done after matching. Randomization of patients will be done by file number using www.random.org site. On this site, the Gaussian randomization method was used with the normal distribution, Blinding description: The Lactulose and Bisacodyl drugs are used in the same way with the same bottle, and patients will not be informed of the type of medication they receive. 3 Acute constipation. Intervention 1: Intervention group (Bisacodyl): Patients will receive 10 mg daily and will be evaluated for at least 5 days for response to treatment. Intervention 2: Control group (Lactulose): Patients will receive 20 gr equal to 15  ml syrup of lactulose daily and will be evaluated for at least 5 days for response to treatment. Yes - There is a plan to make this available What will be shared: demographic data and outcome after deidentification will be available When: Data will be available from 2019 for 1 year To whom: For academic researchers, data will be available Conditions: The use of data will be subject to obtaining a license from the University's Research and Technology Dept. Where to obtain: neurology department, Shahid Beheshti General Hospital, Pezesh St., Ghotbe Ravandi Ave. Postal Code: 8715981151 How to obtain: Information will be obtained from the Department of Research and Technology of the University and correspondence with the Department of Neurology, Shahid Beheshti Hospital of Kashan. Comments: No
public Reza Daneshvar kakhki
Neurology ward, Beheshtei general hospital, Kashan, Isfahan
Kashan Iran (Islamic Republic of) 8715981151 +98 31 5554 0026 daneshvar-r@mail.kaums.ac.ir Kashan University of Medical Sciences scientific Reza Daneshvar kakhki
Neurology ward, Beheshtei general hospital, Kashan, Isfahan
Kashan Iran (Islamic Republic of) 8715981151 +98 31 5554 0026 daneshvar-r@mail.kaums.ac.ir Kashan University of Medical Sciences Iran (Islamic Republic of) Admission within 48 hours of onset of symptoms Definite stroke diagnosis and confirmation with CT-Scan or MRI Acute constipation no limit no limit Both Patients with constipation before stroke History of colon or rectum cancer Constipation caused by metabolic disorder such as hypokalemia Taking drugs that cause constipation, such as anticholinergic drugs or drugs with anticholinergic effects, calcium blockers, etc. History of diabetes mellitus History of myocardial infarction History of hypothyroidism K59.0 Constipation Treatment - Drugs Treatment - Drugs Intervention group (Bisacodyl): Patients will receive 10 mg daily and will be evaluated for at least 5 days for response to treatment. Control group (Lactulose): Patients will receive 20 gr equal to 15  ml syrup of lactulose daily and will be evaluated for at least 5 days for response to treatment. Defication. Timepoint: Daily check for defication after taking drug. Method of measurement: Questionnaire designed by researcher. Kashan University of Medical Sciences Approved 2017-02-08 Ethics committee of Kashan University of Medical Science Pezeshk St., Ghotbe Ravandei ave. Kashan Isfehan Iran (Islamic Republic of)