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IRCT138812013376N1 IRCT 2011-02-16 Vice Chancellor for Research of Shiraz University of Medical Science,Anesthesia department The effect of Magnesium sulphate on increased intra ocular pressure due to general anesthesia The effect of intravenous magnesium sulfate on intraocular pressure changes following tracheal intubation in adults in Shiraz University affiliated hospital 2007-07-23 anticipated 180 Complete https://irct.ir/trial/3451 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention. 3 Persons encountering health services for specific procedures and health care. Intervention 1: administration of magnesium sulphate once 30mg/kg IV before induction of Anesthesia. Intervention 2: administration of normal saline once 30mg/kg IV before induction of Anesthesia.
public Dr Sina Ghaffari pour
Shiraz, Shahid Faghihi Hospital, Department of Anesthesia
Shiraz Iran (Islamic Republic of) 7134844119 +98 71 1233 7636 sina50@gmail.com Shiraz Universityof Medical Science scientific Dr Sina Ghaffari poor
Shiraz, Shahid Faghihi Hospital ,Anesthesia Department
Shiraz Iran (Islamic Republic of) 7134844119 +98 71 1233 7636 sina50@gmail.com Shiraz University of Medical of Science Department of Anesthesia Iran (Islamic Republic of) Inclusion criteria: 180 patients (ASA I) healthy adult, (18 to 38years old, both man and woman) that were scheduled for elective non ocular surgery (ENT and ambulatory surgery that needed tracheal intubation), were selected. exclusion criteria: The patients with specific major hepatic, renal and cardio-vascular disease as well as those known to have allergic reaction to magnesium sulphate or other drugs on basis of the history of patients, and hypermagnesemia, hypocalcemia on the basis on lab data, anuria, heart block (ECG), pregnancy, any degree of renal insufficiency, digitalised patients, positive history of glaucoma, or intra ocular hypertension, and patients who refused to participate in this study, were excluded. 18 years 38 years Both Z40 - Z41 Persons encountering health services for specific procedures and health care Prevention Placebo administration of magnesium sulphate once 30mg/kg IV before induction of Anesthesia administration of normal saline once 30mg/kg IV before induction of Anesthesia Iop (Intra ocular pressure). Timepoint: In 4 stage (T1:Before induction of anesthesia ,T2 :Just before intubation , T3:1 minute after intubation ,T4:5 minute after intubation. Method of measurement: TONOPEN Instrument. Systolic BP. Timepoint: 4 stages ; T1 :Before Induction of anesthesia , T2 : just before intubation ,T3 : 1 minute after intubation, T4 :5 minute after intubation. Method of measurement: NIBP monitoring. Diastolic BP. Timepoint: 4 stages ; T1 :Before Induction of anesthesia , T2 : just before intubation ,T3 : 1 minute after intubation, T4 :5 minute after intubation. Method of measurement: NIBP monitoring. Mean Arterial Pressure. Timepoint: 4 stages ; T1 :Before Induction of anesthesia , T2 : just before intubation ,T3 : 1 minute after intubation, T4 :5 minute after intubation. Method of measurement: NIBP monitoring. Heart Rate. Timepoint: 4 stages ; T1 :Before Induction of anesthesia , T2 : just before intubation ,T3 : 1 minute after intubation, T4 :5 minute after intubation. Method of measurement: EKG monitoring. Vice Chancellor for Research of Shiraz University of Medical Science,Anesthesia department Approved 2008-03-16 Shiraz University of Medical Science Shiraz, Zand avenue, Central building of Shiraz University of Medical Science Shiraz Iran (Islamic Republic of)