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IRCT20180922041084N2 IRCT 2019-01-06 Shiraz University of Medical Sciences Effect of Propofol Cardioplegia Solution on Myocardial Injury Bio marker Effect of Propofol Cardioplegia Solution on Myocardial Injury Bio marker in Coronary Artery Bypass Grafting Surgery 2019-02-26 anticipated 120 Complete https://irct.ir/trial/34655 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: Patients were randomized according to the charts which was derived from www.randomization.com site, Blinding description: A nurse who is unaware of the study groups will provide the cardioplegic solution and will deliver cardioplegic solution to the nurse responsible for anesthesia for injection.The investigators in the operation room and in the ward are unaware of the study groups. 3 atherosclerosis. Intervention 1: Intervention group:Patients in the intervention group received 1200 μg / min propofol by syringe pump as a cardioplegic solution. Intervention 2: Control group: Patients in the control group received cardioplegic solution without adding propofol . Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is It's against our policy.
public Gholam Ali Heidari kochi
Mohammad Rasoul Allah Research Tower, Khalili Street
Shiraz Iran (Islamic Republic of) 7134844119 +98 71 3647 4270 drtabib.maryam@yahoo.com Shiraz University of Medical Sciences scientific Reza Jouybar
Anesthesiology Department, Faghihi Hospital, Zand Street
Shiraz Iran (Islamic Republic of) 7134844119 +98 71 3647 4270 drtabib.maryam@yahoo.com Shiraz University of Medical Sciences Iran (Islamic Republic of) Patient who are candidate for elective Coronary Artery Bypass surgery 30 years 75 years Both Redo surgery Primary troponin level is above 3 μg / L sever Renal failure sever Liver failure congestive Heart Failure grade IV Ejection fraction lower than 30% Allergy to eggs, soy, peanuts I25.1 Atherosclerotic heart disease Prevention Prevention Intervention group:Patients in the intervention group received 1200 μg / min propofol by syringe pump as a cardioplegic solution. Control group: Patients in the control group received cardioplegic solution without adding propofol . Serum level of troponin I. Timepoint: 1st sample just after induction ,2nd sample just after chest closure , 3rd sample 6 hours after arrival to ICU and last sample 24 hours after arrival to the ICU. Method of measurement: Lab test. Serum level of CPKMB. Timepoint: 1st sample just after induction ,2nd sample just after chest closure , 3rd sample 6 hours after arrival to ICU and last sample 24 hours after arrival to the ICU. Method of measurement: Lab test. Arhytmia. Timepoint: During operation and after that. Method of measurement: Monitoring. Shiraz University of Medical Sciences Approved 2018-08-23 Ethics Committee of Shiraz University of Medical Sciences Vice Chancellor of research, Shiraz University of Medical Sciences, 7th floor, central building of Shiraz University of Medical Sciences, Zand street Shiraz Fars Iran (Islamic Republic of)