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IRCT20120527009878N11 IRCT 2019-10-20 Tabriz University of Medical Sciences The effect of medication on reducing lumbar pain Role of clonidine in management of pain after lumbar discectomy 2640-01-26 anticipated 60 Pending https://irct.ir/trial/34755 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients will be randomly divided into case and control groups. Randomization will be done using the Gaussian command at www.random.org, Blinding description: Two engines will be used in place of placebo and in a clinical trial in two parallel groups. During the entire study period, patients, staff and surgeons will be unaware of the two main study arms. The use of Visual Analogue Scale (VAS) will be done to measure pain in the lower limbs and wrists of patients receiving Clonidine and placebo. Clonidine used in the form of capsules and 2 hours before surgical intervention will be given to patients in the study group. Oral Gabapentin begins with a standard dose for the patient. The placebo capsule, taken in the shape and size and color and weight of the actual drug by the head nurse, is considered to be blind to 2 hours before surgery. Two arms of control and case will be mediation by an anesthetic protocol and a profile. 2 Post-procedural Pain. Intervention 1: Intervention group: Clonidine produced by Zahravi Tabriz Company will be given orally to the patients in the form of 0.2 mg tablet twice daily. Intervention 2: Control group: Placebo produced by Zahravi Tabriz Company will be given orally to the patients in the form of 0.2 mg tablet twice daily. Yes - There is a plan to make this available What will be shared: All data is available for sharing. When: Start the access period 3 months after printing the results To whom: Only for researchers working in academic and scientific institutions Conditions: Research and Therapeutic Use Where to obtain: Resident of neurosurgery at Imam Reza Hospital 09143141602 How to obtain: Three months after publication of results, the writing request were submitted in the Office of the Department of neurosurgery at Imam Reza Hospital in Tabriz and will be contacted with the relevant resident. Comments:
public Javad Aghazade
Tabriz university of medical science
Tabriz Iran (Islamic Republic of) 5165686713 +98 41 3333 8397 jaghazadeh56@yahoo.com Tabriz University of Medical Sciences scientific Javad Aghazade
Tabriz university of medical science
Tabriz Iran (Islamic Republic of) 5165686713 +98 41 3333 8397 jaghazadeh56@yahoo.com Tabriz University of Medical Sciences Iran (Islamic Republic of) Age of 18 to 70 years Weight 60 to 80 kg Having satisfaction Adherence of clinical signs and symptoms to MRI findings The presence of a disc in a lumbar space in an MRI 18 years 70 years Both History of lumbar surgery Drug or Alcohol Addiction Pregnancy and lactation Previous use of the same drugs Seizures and other neurological diseases Intervention over a diskette only involves the use of a discectomy or diskette over a disk space Use of other medications the day before or after surgery (unwanted) The patient's disability is due to retardation, aphasia, visual impairment, and other things that prevent the patient from communicating. The patient's over-standard need for opioid and analgesic neuropathic drugs History of obstructive peripheral vascular disease G89.18 Other acute postprocedural pain Treatment - Drugs Treatment - Drugs Intervention group: Clonidine produced by Zahravi Tabriz Company will be given orally to the patients in the form of 0.2 mg tablet twice daily. Control group: Placebo produced by Zahravi Tabriz Company will be given orally to the patients in the form of 0.2 mg tablet twice daily. Post-operative pain. Timepoint: Clonidine used in capsule form and 2 hours before surgical intervention in the case group will be given to patients. After surgery for the first 24 hours and at the end of 6 hours, one physician who is blind to the study will record the parametric / VAS pain rate in the sheet. The amount of Opioid ingestion in the first 24 hours after surgery will also be measured for each patient. Method of measurement: Using VAS (virtual analogue scale) to measure pain in the lower extremities and wrists of patients receiving clonidine and placebo. Tabriz University of Medical Sciences Approved 2018-08-27 Ethics committee of Tabriz university of medical sciences Floor 3, Center building N 2, Tabriz university of medical sciences, Golgasht street. Tabriz East Azarbaijan Iran (Islamic Republic of)