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IRCT20150519022320N18 IRCT 2019-01-27 Rafsanjan University of Medical Sciences Comparison of the effects of relaxation and meditation techniques on serum levels of IL-10, TGF-β, IL-6 and IFN-γ Comparison of the effects of relaxation and meditation techniques on serum levels of IL-10, TGF-β, IL-6 and IFN-γ in the patients with Coronary Artery Disease 2018-12-04 anticipated 90 Complete https://irct.ir/trial/34964 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Basic scienece, Randomization description: The sampling will be based on objective criteria for inclusion. After obtaining informed consent, subjects randomly to be divided into groups. By random numbers, each person is assigned a number. They were then randomly assigned to relaxation and meditation groups, Blinding description: Experiments are conducted by a researcher who does not know about the grouping of participants in the study. N/A Atherosclerotic heart disease. Intervention 1: Intervention group 1: A relaxation program will be planned and implemented in seven stages for the relaxation group, the steps of which will be:1. Identify the muscles and muscle groups of the case, 2- Training on progressive muscle relaxation technique using its explanation and practical presentation by the researcher,3- Answering the patient's questions about the relaxation technique 4- Performing the technique by the researcher using an audio tape, or educational CD 5- Performing the technique by the patients along with the researcher, 6- Statement of difference in physical and mental feelings of samples after relaxation 7- Performing the technique by samples and under the supervision of the researcher. In relaxation, patients will be asked to first shrink and then loosen the muscles of the muscles of the foot to the muscles of the face, including 16 muscles. Patients relax their muscles by counting up to number 5 and then relaxing by counting up to 10.The same steps will be repeated for the legs, legs, thighs, abdomen, chest, hips, arms and forearms, arms, shoulders, neck, forehead, tongue and jaw, eyes and face until all of their bodies Loose integrated.At the same time, patients breathe deeply during relaxation. The state of choice for gradual relaxation is lying. The patient will perform this exercise until the difference between the contraction and the muscle tone is felt and expressed.In this way, the method will be taken and can take this method alone and using a tape. After ensuring the correct understanding and correctness of the procedure, audio cassettes and CDs will be provided to patients for the implementation of relaxation steps. And they spend three months (three times a week) one day in a row and for a half an hour under the supervision of the researcher (a total of 36 sessions). Intervention 2: Intervention group 2: To perform meditation, the patient is asked to be in a comfortable position and perform a deep inhale with 3 numbers and a deep exhalation with 4 numbers; Meditation for 8 weeks, 3 days a week, and 15 to 20 minutes per day in two steps in the morning and in the evening. Intervention 3: Control group: 30 people with coronary artery disease without any intervention. Blood samples are taken before and three months after the study. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Confidentiality of information
public Tayebeh mirzaei
Parastar Ave.
Rafsanjan Iran (Islamic Republic of) 7718796755 +98 34 3452 5900 t.mirzaei@rums.ac.ir Rafsanjan University of Medical Sciences scientific Mohammad Kazemi Arababadi
Parastar Ave.
Rafsanjan Iran (Islamic Republic of) 7718796755 +98 34 3425 5900 kazemi24@yahoo.com Rafsanjan University of Medical Sciences Iran (Islamic Republic of) Known coronary artery disease (based on medical records) Background in the CCU Lack of history of mental illness or lack of use of psychoactive drugs Desire to participate in the study Lack of heart failure Lack of autoimmune diseases, allergies and immune-related diseases Age range 45 to 75 years 45 years 75 years Both I25 Chronic ischemic heart disease Lifestyle Lifestyle N/A Intervention group 1: A relaxation program will be planned and implemented in seven stages for the relaxation group, the steps of which will be:1. Identify the muscles and muscle groups of the case, 2- Training on progressive muscle relaxation technique using its explanation and practical presentation by the researcher,3- Answering the patient's questions about the relaxation technique 4- Performing the technique by the researcher using an audio tape, or educational CD 5- Performing the technique by the patients along with the researcher, 6- Statement of difference in physical and mental feelings of samples after relaxation 7- Performing the technique by samples and under the supervision of the researcher. In relaxation, patients will be asked to first shrink and then loosen the muscles of the muscles of the foot to the muscles of the face, including 16 muscles. Patients relax their muscles by counting up to number 5 and then relaxing by counting up to 10.The same steps will be repeated for the legs, legs, thighs, abdomen, chest, hips, arms and forearms, arms, shoulders, neck, forehead, tongue and jaw, eyes and face until all of their bodies Loose integrated.At the same time, patients breathe deeply during relaxation. The state of choice for gradual relaxation is lying. The patient will perform this exercise until the difference between the contraction and the muscle tone is felt and expressed.In this way, the method will be taken and can take this method alone and using a tape. After ensuring the correct understanding and correctness of the procedure, audio cassettes and CDs will be provided to patients for the implementation of relaxation steps. And they spend three months (three times a week) one day in a row and for a half an hour under the supervision of the researcher (a total of 36 sessions). Intervention group 2: To perform meditation, the patient is asked to be in a comfortable position and perform a deep inhale with 3 numbers and a deep exhalation with 4 numbers; Meditation for 8 weeks, 3 days a week, and 15 to 20 minutes per day in two steps in the morning and in the evening. Control group: 30 people with coronary artery disease without any intervention. Blood samples are taken before and three months after the study. Measuring the level of serum IL-6. Timepoint: Before the study and three months after the start of the study. Method of measurement: ELISA test. Measuring the level of serum IL-10. Timepoint: Before the study and three months after the start of the study. Method of measurement: ELISA test. Measuring the level of serum TGF-β. Timepoint: Before the study and three months after the start of the study. Method of measurement: ELISA test. Measuring the level of serum IFN-. Timepoint: Before the study and three months after the start of the study. Method of measurement: ELISA test. Rafsanjan University of Medical Sciences Approved 2018-10-20 کمیته اخلاق در پژوهش دانشگاه علوم پزشکی رفسنجان بلوار امام علی،سازمان مرکزی سازمان مرکزی دانشگاه علوم پزشکی رفسنجان Kerman Iran (Islamic Republic of)