IRCT20141118019991N2 IRCT 2019-10-16 Shahid Beheshti University of Medical Sciences Evaluating the effect of oropharyngeal colostrum in very low birth weight premature infant. LBW Evaluating the effect of oropharyngeal colostrum administration from the first day of life in very low birth weight premature infant 2019-11-21 anticipated 50 Complete https://irct.ir/trial/35216 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Utilizing "RAS", permuted randomization was conducted on the sample population. Permuted Block Randomization of the Individual type was performed. The allocation concealment was done by The Data Safety and Monitoring Center of Shohadaye Tajrish Hospital's Clinical Research Development Department, Blinding description: This study was a double-blinded study in which the patients, the nurses, the conductors, and the analyst _who later joined the research team and was not a member initially _ were not aware of the sampling procedures and the method by which randomly chosen treatments were administered to the patients.The method was carried out and authorized by "The Safety and Monitoring Committee.". 2 Condition 1: Sepsis. Condition 2: Narcotizing Enterocolitis. Condition 3: Mortality. Condition 4: Hospitalization Duration. Condition 5: Full Fed time. Intervention 1: Intervention group: Oropharyngeal administration of 0.2 cc Colostrum was started at the first hour of life, It was given every 3 hour for 3 days. Intervention 2: Control group: Breast Milk Minimal Enteral Feeding administration was started after 72 hours of life. No - There is not a plan to make this available Justification or reason for not sharing IPD is No more information.