IRCT20181114041658N1 IRCT 2019-02-24 Shiraz University of Medical Sciences Comparing dimethyl sulfoxide solution versus topical tretinoin in cutaneous amyloidosis Comparing the efficacy of 50% dimethyl sulfoxide solution versus topical tretinoin 0.5% cream in patients with cutaneous amyloidosis 2019-03-21 anticipated 10 Complete https://irct.ir/trial/35313 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: We use simple randomization by the random number table in order to generate random sequence. To this end, a biostatistician employs the random allocation software and after obtaining the reading trend, the first number will assign to the right side and the second number will assign to the left side. The odd number and even number represent the intervention and control sides, respectively. Therefore, dimethyl sulfoxide and tretinoin will be assigned for each side (right or left). Then, allocation concealment will be done using SNOSE method and numbered, sealed and opaque envelopes by a medical doctorate candidate will be sequenced and will be delivered to the principal dermatologist. In time of enrolling the participants to the study who is fulfilled the inclusion criteria, evaluated by the dermatologist, two consecutive envelops will be open and the allocated sides will be obtained. Each patient will serve as his/her own control; by doing so, the problem of confounding factor will be avoided. Also, for concealment, we will use similar containers in shape and color, Blinding description: Although the treatments were allocated randomly, the patients were aware of the treatments (dimethyl sulfoxide solution and tretinoin cream can be distinguished). They instructed by a blinded dermatologist (Researchers will be blinded to the allocation until the end of study. To conceal group allocation, we use similar containers in shape and color) to apply treatments daily in the first four weeks and every other day later on. Notably, tubes are identical and based on list and number on tubes, will be assigned to each side in every patient. Also, the baseline outcomes will record. Patients reattended and further colorimetery, itching scoring, and photography were then undertaken at the end of 4th, 12th, and 18th week follow ups with the dermatologist unaware of the treatments’ side which the volunteer had been randomized. َAdditionally, dermatologist will record the outcomes as well. Data analysis will be done by an epidemiologist who is unaware of treatments. 3 Primary localized cutaneous amyloidosis. Intervention 1: Intervention group receives topical dimethyl sulfoxide (DMSO) 50% solution (formulized and prepared at the School of Pharmacy, Shiraz University of Medical Sciences) on the assigned side daily for 4 weeks and every other day to the 20th week. After cleansing the target lesion with water and soap, topical DMSO 50% solusion applies by a spigot. Intervention 2: Control group uses tretinoin 0.5% (Iran Daroo, Tehran, Iran) on the assigned side daily for 4 weeks and every other day to the 20th week. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information.