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IRCT20180908040964N1 IRCT 2018-12-31 Shahid Beheshti University of Medical Sciences Comparision The Effect of Minimal stimulation and double stimulation protocol in poor ovarian response in ICSI cycle Comparision The Effect of Minimal stimulation and double stimulation protocol in poor ovarian response in ICSI cycle 2017-10-23 anticipated 60 Complete https://irct.ir/trial/35324 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: We use the numerical random number table to choose the numbers, for example, if the sample size is two digits. First, select a two-digit number completely randomly, for example by placing the pencil tip, and then go ahead and select two-digit numbers to get the required number, Blinding description: This is double-blind study, that the participants do not know which of the two control or test groups belong, and also the observers (researchers) do not know who the group is. 2-3 Patients with poor ovarian response. Intervention 1: Intervention group1: In a double-stimulation protocol based on the Shanghai protocol, Qualified women entered the study in the first phase from the third day of the monthly cycle will receive a daily dose of 25 mg cholomifen citrate for up to a stimilation day. At the same time, letrozole at a dose of 2.5 mg per day from the third day for four days at 150 units, every other day will start. And will receive HMG on the 10th day. When at least 3 follicules have reached 18 mm or a follicle reached 20 mm, the triggering of oocyte with an GNRH agonist will start. 32 to 36 hours after an agonist GNRH injection search and retrieve oocytes from transvaginal sonography will begin and follicles less than 10 mm will remain to second phase in the luteal phase. After ultrasonography, the second phase of stimulition depends on presence of at least 2 anthral follicles with a size of 2 to 8 mm. At this stage 225 Unit HMG with 2.5 mg Letrozole is prescribed daily from the day of recovery of oocyte or one day later. And when the dominant follicle reached 12mm, Letrozole is discontinued and daily administration of medroxyprogesterone acetate at a dose of 10 mg for 3 days will continue for patients with follicles up to 14 cm. And when at least 3 follicules have reached 18 mm or a follicle reached 20 mm,the triggering of oocyte with an GNRH agonist will start again. Intervention 2: Intervention group: In the minimum protocol, colomibsin citrate is prescribed from day 2 to day 5 of the monthly cycle with a dose of 100 mg / day. From day four, 150 HMG units are prescribed. The GNRH antagonist is administered when the dominant follicle reaches 13 or higher and continues until the final trigger day. The ovulation stimulation is performed when the dominant follicle reaches 17 mm.In this HCG recombinant mcg is prescribed. Yes - There is a plan to make this available What will be shared: In this study, the results of the study based on the initial outcome Will be shared. All of the data can be shared after unidentifiable Participants When: Without restriction To whom: All researchers Conditions: With permission from the author responsible Where to obtain: Email to author responsible How to obtain: Email to author responsible Comments:
public Sediqeh Hosseini
Taleghani hospital, Yaman st., Velenjak, Chamran highway
Tehran Iran (Islamic Republic of) 1983969411 +98 21 2243 2558 shosseini@sbmu.ac.ir Shahid Beheshti University of Medical Sciences scientific Sediqeh Hosseini
Taleghani hospital, Yaman st., Velenjak, Chamran highway
Tehran Iran (Islamic Republic of) 1983969411 +98 21 2243 2558 shosseini@sbmu.ac.ir Shahid Beheshti University of Medical Sciences Iran (Islamic Republic of) In these individuals, the previous cycle was canceled due to insufficient ovarian response. After ovarian stimulation in the previous cycle, less than three follicles and after puncture, less than one ovum were obtained. 20 years 38 years Female N98.9 Complication associated with artificial fertilization, unspecified Treatment - Drugs Treatment - Drugs Intervention group1: In a double-stimulation protocol based on the Shanghai protocol, Qualified women entered the study in the first phase from the third day of the monthly cycle will receive a daily dose of 25 mg cholomifen citrate for up to a stimilation day. At the same time, letrozole at a dose of 2.5 mg per day from the third day for four days at 150 units, every other day will start. And will receive HMG on the 10th day. When at least 3 follicules have reached 18 mm or a follicle reached 20 mm, the triggering of oocyte with an GNRH agonist will start. 32 to 36 hours after an agonist GNRH injection search and retrieve oocytes from transvaginal sonography will begin and follicles less than 10 mm will remain to second phase in the luteal phase. After ultrasonography, the second phase of stimulition depends on presence of at least 2 anthral follicles with a size of 2 to 8 mm. At this stage 225 Unit HMG with 2.5 mg Letrozole is prescribed daily from the day of recovery of oocyte or one day later. And when the dominant follicle reached 12mm, Letrozole is discontinued and daily administration of medroxyprogesterone acetate at a dose of 10 mg for 3 days will continue for patients with follicles up to 14 cm. And when at least 3 follicules have reached 18 mm or a follicle reached 20 mm,the triggering of oocyte with an GNRH agonist will start again. Intervention group: In the minimum protocol, colomibsin citrate is prescribed from day 2 to day 5 of the monthly cycle with a dose of 100 mg / day. From day four, 150 HMG units are prescribed. The GNRH antagonist is administered when the dominant follicle reaches 13 or higher and continues until the final trigger day. The ovulation stimulation is performed when the dominant follicle reaches 17 mm.In this HCG recombinant mcg is prescribed. Number of follicles. Timepoint: From the tenth day of the cycle. Method of measurement: sonography. Number of recovered oocytes. Timepoint: Oocyte recovery day. Method of measurement: observation. Number of canceled cycles. Timepoint: Oocyte recovery da. Method of measurement: observation. Number of embryo. Timepoint: 5 days after Oocyte recovery. Method of measurement: observation. Embryo grading. Timepoint: 5 days after Oocyte recovery. Method of measurement: observation. Transmitted embryos. Timepoint: Transfer day. Method of measurement: observation. Pregnancy rate. Timepoint: Two weeks after transfer. Method of measurement: blood test. Shahid Beheshti University of Medical Sciences Approved 2018-04-29 Ethics committee of Shahid Beheshti University of Medical Sciences Velenjak, Yaman St, Chamran highway Tehran Tehran Iran (Islamic Republic of)