IRCT20130811014330N7 IRCT 2019-12-26 Mashhad University of Medical Sciences Effect of Curcumin in Treatment of Pediatric Intractable Epilepsy The Effect of Curcumin on Reducing the Number of Seizures and Inflammatory Cytokines in Patients with Intractable Pediatric Epilepsy 2015-07-23 anticipated 22 Complete https://irct.ir/trial/35406 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Crossover, Purpose: Treatment, Randomization description: The patients were randomly allocated to two groups by simple randomization based on computer-generated random numbers. Sealed drug containers were used in order to conceal the treatments to the clinician and patients, Blinding description: The clinician, parents, patients and the researchers were unaware of the contents of drug or placebo containers. Sealed drug containers were used in order to conceal the treatments to the clinician and patients. 3 Pediatric intractable epilepsy. Intervention 1: Intervention group 1: Patients were given 4 mg/kg curcumin solution daily for four weeks (Sinacurcumin®, each drop of solution contains 4 mg nanocurcumin). After a two-week washout period, the drug was replaced with the placebo, and the patient received 4 mg/kg placebo for another four weeks. Intervention 2: Intervention group 2: Patients were given 4 mg/kg placebo daily for four weeks. After a two-week washout period, the placebo was replaced with the drug, and the patient received 4 mg/kg curcumin solution (Sinacurcumin®, each drop of solution contains 4 mg nanocurcumin) for another four weeks. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information.