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IRCT20181204041844N1 IRCT 2020-06-02 Kerman University of Medical Sciences evaluation the effect of henna mouthwash on oral lichen planus Comparison the effect of Chlorhexidine gluconate 0.2% mouthwash with Henna mouthwash as adjuvant therapy on oral lichen planus 2018-09-23 anticipated 40 Complete https://irct.ir/trial/35733 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization will be performed by the Randlist software and each patient will be entered in the treatment or control group, Blinding description: Randomization and allocation will be concealed from the researcher and participants until the final analyses are completed. The researcher at the Kerman dental school, who is not aware of random sequences, will deliver the participants to 250cc opaque glass containers that have a similar appearance and contain a mouthwash.The taste and smell of henna and chlorhexidine mouthwashes are similar due to its 2% ethanol content. 3 "oral lichen planus". Intervention 1: Intervention group:Mouthwash 2% of the aqueous extract of Henna plant in the presence of other mouthwash compounds containing 0.1% w / w of methyl parahydroxybenzoate, 2% ethanol, 10% glycerol, distilled water twice a day (morning and evening) and each time 5 ml of the mouthwash for 30 seconds should be used.Gargle with betamethasone lotion four times a day (after meals and at bedtime) for one minute. Intervention 2: Control group: 0.2% chlorhexidine gluconate mouthwash and Iranian betamethasone lotion available on the market twice a day (morning and evening) and each time 5 ml of the mouthwash for 30 seconds should be used.Gargle with betamethasone lotion four times a day (after meals and at bedtime) for one minute. Yes - There is a plan to make this available What will be shared: all collected deidentified IPD. IPD collected for primary outcome measure only. When: 6 months after publication To whom: it will be available for people working in academic institutions. Conditions: people working in academic institutions Where to obtain: sov.karbasi@gmail.com dr.nahid.karbasi How to obtain: request containing how the data will be used must be applied via email. citation in future publication is mandatory. data will be sent within 3 months. Comments:
public Nahid Karbasi
Kerman,Islamic Republic Boulevard,End of Shafa Street,Kerman Dental School
kerman Iran (Islamic Republic of) 7618759689 +98 34 3211 9021 sov.karbasi@gmail.com Kerman University of Medical Sciences scientific Nahid Karbasi
Kerman,Islamic Republic Boulevard,End of Shafa Street,Kerman Dental School
kerman Iran (Islamic Republic of) 7618759689 +98 34 3211 9021 sov.karbasi@gmail.com Kerman University of Medical Sciences Iran (Islamic Republic of) Presence of atrophic and/or erosive lesions of the oral mucosa Painful lesions Histological confirmation of the diagnosis of oral lichen no limit no limit Both presence of dysplasia in the histopathological study of OLP patients on long-term corticosteroid therapy the use of drugs capable of inducing lichenoid reactions L43 Lichen planus Treatment - Drugs Treatment - Drugs Intervention group:Mouthwash 2% of the aqueous extract of Henna plant in the presence of other mouthwash compounds containing 0.1% w / w of methyl parahydroxybenzoate, 2% ethanol, 10% glycerol, distilled water twice a day (morning and evening) and each time 5 ml of the mouthwash for 30 seconds should be used.Gargle with betamethasone lotion four times a day (after meals and at bedtime) for one minute. Control group: 0.2% chlorhexidine gluconate mouthwash and Iranian betamethasone lotion available on the market twice a day (morning and evening) and each time 5 ml of the mouthwash for 30 seconds should be used.Gargle with betamethasone lotion four times a day (after meals and at bedtime) for one minute. Pain intensity. Timepoint: before intervention and 7,14 days after intervention. Method of measurement: Visual Analogue Scale. Clinical presentation or inflammation. Timepoint: before intervention and 7,14 days after intervention. Method of measurement: Thongprasom sign Scoring. Kerman University of Medical Sciences Approved 2639-09-19 Ethics committee of Kerman University of Medical Sciences Kerman, the center of seven Alavi Gardens, Campus of Kerman University of Medical Sciences kerman Kerman Iran (Islamic Republic of)