IRCT20110606006709N19 IRCT 2019-04-14 Tabriz University of Medical Sciences The effect of Nigella sativa oil soft capsule on early menopausal symptom and oxidative markers Comparing the effect of Nigella sativa oil soft capsule and placebo on early menopausal symptom and serum levels of some oxidative markers in Postmenopausal women: A triple blind randomized controlled clinical trial 2018-12-26 anticipated 72 Complete https://irct.ir/trial/35757 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Menopausal women aged 45- 60 years or older will be randomly assigned into two groups of recipients of training or control using random blocking method and blocks of size 4 and 6 using Random Allocation Software (RAS) with a 1: 1 assignment ratio by the person not involved in the research. To conceal the allocation, the name of group will be placed inside a consecutively numbered sealed opaque envelopes. Preparation of envelopes and sequence generation will be done by a person not involved in participant recruitment or data collection, Blinding description: The drug and the placebo will be prepared by the same pharmaceutical company in identical shape, color and smell. Investigators, health care providers, outcome assessors, and statistical analyst will be blinded. 3 menopause. Intervention 1: Intervention group: They will use Nigella Sativa oil soft capsule 1000 mg once a day prepared by Baryj Essence pharmaceutical company, orally for 8 weeks. Intervention 2: Control group:They will use Nigella Sativa placebo soft capsule containing 1000 mg Lactose once a day, prepared by Baryj Essence pharmaceutical company, orally for 8 weeks. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is After the completion of the project, the decision will be made.