IRCT20130418013058N13 IRCT 2019-07-30 Mashhad University of Medical Sciences Effect of Crocin on mild to moderate maculopathy Monotherapy effect of Crocin on mild to moderate maculopathy; a clinical trial study 2018-12-31 anticipated 40 Complete https://irct.ir/trial/35763 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: For each tablet container, four-digit codes will be Randomly labeled to Each Box by pharmacist . The Therapist will give it to the Patient Randomly without Knowledge of the Type of Medicine. Thus, the Nature of Each Code will be Unclear Until the Analysis of the Results, Blinding description: Crocin and Placebo Tablets will be prepared in a Similar Shape, Color, and Size, stored in a Dark Container and coded by a Pharmacist. The Treating Physician, Researcher, and Patients will not be Aware of the Code printed on the Container. 2-3 Diabetic Retinopathy. Intervention 1: Intervention group: Receiving One Tablet of Crocin (15 mg)daily for three Months. Intervention 2: Control group: Receiving One Tablet of Placebo daily for three Months. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Due to, the work has not begun, a Definitive Decision has not been made For these data.