IRCT20160206026390N11 IRCT 2019-06-10 Mashhad University of Medical Sciences Probiotics and children under hemodialysis treatment Evaluation of the Efficacy of Probiotic Supplementation on bio-markers of inflammation and oxidative stress in pediatric patients under treatment with hemodialysis: randomized double blind clinical trial 2018-12-22 anticipated 20 Complete https://irct.ir/trial/35899 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: Simple randomization based on envelops Allocation Concealment Sequentially numbered, opaque, sealed envelopes, Blinding description: Blinding for patients performed based on placebo drugs which is based on placebo which is same in color, form and size Physician is not informed about allocation in groups Data analyzer do not know about groups. N/A Pediatric under hemodialysis treatment. Intervention 1: Intervention group: Probiotic Intervention group receive probiotics Probiotic contain following strains : Lactobacillus casei ،Lactobacillus acidophilus ، Lactobacillus rhamnosus ، Lactobacillus bulgaricus، Bifidobacterium breve ، Bifidobacterium longum و Streptococcus thermophilus in the count of 109 CFU in 500 mg tablet from Zist Takhmir. Because these Bactria remain in the intestine and not absorb, nothing uptake during dialysis. Intervention 2: Control group: placebo same in form, color and size. No - There is not a plan to make this available Justification or reason for not sharing IPD is only with permission with supporter organization and also ethics committee would be shared.