]>
IRCT20181211041930N1 IRCT 2018-12-22 Yazd University of Medical Sciences The effect of two kinds of triggering with GnRh agonist in antagonist protocol A comparison between the effect of two kinds of triggering with GnRh agonist in PCOS patients treated by antagonist protocol for ART on oocyte and embryo quality 2018-12-10 anticipated 120 Complete https://irct.ir/trial/35921 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: At first we choose 112 patients who met the inclusion criteria ,and 1 to 112 numbers were assigned to each participants consecutively. The patients were divided into two 56-participant groups by using random allocation soft ware and random codes generation. At the time of patients' visit, they were allocated into two groups based on their random generated numbers. 2 Triggering with different doses of GnRh a in PCO patients. Intervention 1: Intervention group: The intervention group were triggered by injection of decapeptyl 0.2 mg, following by the second dose of decapeptyl 0.1 mg after 12 hours. Intervention 2: Control group: The control group was triggered by decapeptyl 0.2 mg. Yes - There is a plan to make this available What will be shared: The study protocol, the statistical analysis map, the clinical study report will be available after the publishing of the article . When: After publishing the article To whom: Researchers working in academic institutions Conditions: Use in the retrospective studies Where to obtain: Yazd Research and Clinical Center for Infertility How to obtain: Request from the Research Deputy, submitted to the Research Council of the Center if the request accepts its referral to the security and after completion of the relevant forms, the request is referred to the research experts and then get the data. Comments:
public Masrooreh Hoseini
Bou-Ali, Safaeyeh, Research and Clinical Center for Infertility
Yazd Iran (Islamic Republic of) 8916877391 +98 35 3824 7085 masroorehoseini@yahoo.com Yazd University of Medical Sciences scientific Abbas Aflatoonian
Bou_Ali, Safaeyeh, Research and Clinical Center for Infertility
Yazd Iran (Islamic Republic of) 8916877391 +98 35 3824 7085 abbas_aflatoonian@yahoo.com Yazd University of Medical Sciences Iran (Islamic Republic of) PCOS women based on Rotterdam criteria who were candidate for ART Serum estradiol level more than 3000 pg/ml on triggering day Ovarian stimulation with GnRH antagonist protocol Age between 20-38 years Body Mass Index > 18 and < 30 20 years 38 years Female Sever endometriosis Sever male factor infertility Uterine anomaly Metabolic disease N97.9 Female infertility, unspecified Treatment - Drugs Treatment - Drugs Intervention group: The intervention group were triggered by injection of decapeptyl 0.2 mg, following by the second dose of decapeptyl 0.1 mg after 12 hours. Control group: The control group was triggered by decapeptyl 0.2 mg. The number of mature oocytes (MII). Timepoint: After oocyte retrieval. Method of measurement: Counting mature oocyte under microscopy. Number of 2PNs. Timepoint: 16 hours After fertilization. Method of measurement: Counting 2PNs under microscopy. OHSS developing. Timepoint: Days 4 and 7 post oocyte pick-up. Method of measurement: Measuring ovarian size, presence of free fluid in Douglas. Embryos quality and embryo count. Timepoint: 48 hours after fertilization. Method of measurement: Assessment under microscopy by embryologist. Yazd University of Medical Sciences Approved 2018-12-02 Ethics committee of Shahid Sadoughi University of Medical Science Bou_Ali Ave, Safayieh Yazd Yazd Iran (Islamic Republic of)