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IRCT201405313485N4 IRCT 2014-09-09 Vice Chancellor for Research, Guilan University of Medical Sciences, Rasht, Iran The effect of tranexamic acid on blood loss during and after cesarean in women who candidate for cesarean section delivery The effect of tranexamic acid on blood loss during and after cesarean in women who candidate for cesarean section delivery by clinical trial study 2014-08-23 anticipated 80 Complete https://irct.ir/trial/3598 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 2 Labour and delivery complicated by intrapartum haemorrhage, not elsewhere classified. Intervention 1: Giving 1g intra venous tranexamic acid diluted with 20cc dextrose water 5% in 15min before skin incision. Intervention 2: Giving 1g intravenous distilled water as placebo diluted with 20cc dextrose water 5% in 15min before skin incision.
public Dr. Forozan Milani
Reproductive Health Research Center, Alzahra hospital, Namjoo street
Rasht Iran (Islamic Republic of) +98 13 1322 5624 forozanmilani@yahoo.com Guilan University of Medical Sciences scientific Dr. Forozan Milani
Reproductive Health Research Centre, Alzahra Hospital, Namjoo Street
Rasht Iran (Islamic Republic of) +98 13 1322 5624 forozanmilani@yahoo.com Guilan University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Primiparas and multiparas females with singleton pregnancy during the gestational ages of 37 to 40 weeks who are going to be delivered by cesarean section through fannenstiel’s incision and spinal anesthesia Non-inclusion criteria: Patients with problem of heart, liver and kidney; hematologic or rheumatologic problems; history of thyroid disease; abnormal placental; severe preeclampsia; macrosomia; severe anemia; problematic obstetric history Exclusion criteria: allergy to Tranexamic acid 135 years 137 years Female 0.72 postpatrum-haemorrhage Treatment - Drugs Treatment - Drugs Giving 1g intra venous tranexamic acid diluted with 20cc dextrose water 5% in 15min before skin incision Giving 1g intravenous distilled water as placebo diluted with 20cc dextrose water 5% in 15min before skin incision Blood loss during and two hours after surgery. Timepoint: During surgery until two hours. Method of measurement: Measuring the weight of bloody gauzes, pads and cloths during and two hours after the surgery and the amount of blood from the suction machine during the surgery. The need of blood transfusion. Timepoint: To 48 hours after a cesarean section. Method of measurement: Checking of hemoglobin and hematocrit during 12 to 24 hours after the surgery and checking vital signs every 4 hours. The need of hysterectomy. Timepoint: To 48 hours after a cesarean section. Method of measurement: Checking vital signs and examination for Atonic uterus and abnormal vaginal bleeding every 4 hours. Vice Chancellor for Research, Guilan University of Medical Sciences, Rasht, Iran Approved 2014-08-19 Vice Chancellor for Research, Guilan University of Medical Sciences Vice Chancellor for Research, Namjoo Street Rasht Iran (Islamic Republic of)