IRCT20090813002342N12 IRCT 2020-12-31 Mazandaran University of Medical Sciences Once or twice daily dose of phenobarbital to control seizure in neonates The efficacy of intravenous phenobarbital as once or twice daily dose in neonates with seizure in NICU 2017-09-23 anticipated 24 Complete https://irct.ir/trial/36120 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: By simple randomization method, patients who met the inclusion criteria and completed informed consent were assigned to two groups. Random number generation software (using www.random.org) determined a number for each patient, if the number was odd, the patient was assigned to group 1 and if it was even, the patient was assigned to group 2. The randomization process was performed by the ward supervisor (who was independent of the principal investigators). Randomization was performed when the patient entered the study and the intervention was assigned according to his group therapy, Blinding description: If phenobarbital was prescribed for a baby due to seizures, it was written by the treating physician and the trained head nurse placed the baby in group 1 or 2 according to a random code obtained from www.random.org (odd or even). Due to the different ways of using phenobarbital, we were able to blind only the outcome assessor and data analyst to the study groups. All patients received intravenous phenobarbital with an initial dose of 20 mg / kg and, if necessary, increased by 10 mg / kg every 5 minutes to a maximum of 40 mg / kg. Then, group 1 patients received a single maintenance dose of 5 mg / kg. The daily dose and group 2 patients also received 5.2 mg / kg every 12 hours. 3 Convulsions of newborn. Intervention 1: Group 1 (once daily): Patients were received intravenous (IV) phenobarbital with an initial dose of 20 mg/kg and as needed with an increase of 10 mg/kg every 15 minutes to a maximum of 40 mg/kg and a maintenance dose of 5 mg/kg/day for 5 days. All of phenobarbital ampules (200 mg/ml) were prepared from Darou Pakhsh Co. Iran. Drug was administered at a maximum rate of 1 mg/kg/min as intravenous infusion. Intervention 2: Group 2 (twice daily): Patients were received IV phenobarbital with an initial dose of 20 mg/kg and, if necessary, an increase of 10 mg/kg every 15 minutes up to a maximum of 40 mg/kg, followed by a dose of 2.5 mg/kg every 12 hours for 5 days. The first maintenance dose was used 12 hours after the loading dose. All of phenobarbital ampules (200 mg/ml) were prepared from Darou Pakhsh Co. Iran. Drug was administered at a maximum rate of 1 mg/kg/min intravenous infusion. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is not enough permission to disseminate patient information.