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IRCT20140221016666N3 IRCT 2019-01-19 Mazandaran University of Medical Sciences Efficacy of topical curcumin on mild to moderate idiopathic carpal tunnel syndrome CTS: carpal tunnel syndrome Efficacy of topical curcumin on mild to moderate Idiopathic carpal tunnel syndrome: a randomized double-blind placebo controlled clinical trial 2018-09-23 anticipated 70 Complete https://irct.ir/trial/36138 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The case group uses the topical curcumin form two times daily, and the placebo is given to the control group. Sample selection based on Simple Block Randomized.All patients should avoid doing activities that require Extention and Flexion wrists.Medications and placebo make the Nanocin Healthcare company. Both are in the tubes of the same shape and have the same color and density. Both groups use night-time splint, and medications are used once in the morning and once in the evening. The course is for eight weeks and all patients are evaluated at the end of the eighth week. To evaluate patients from the Visual Analog Scale (VAS) and Boston's questionnaire are used. All results are recorded by the neurologist, which is Blind, Blinding description: Patients and assessors are blind. 1-2 Carpal tunnel syndrome. Intervention 1: Intervention group: Curcumin topical ointment is a turmeric extract and is manufactured by Exir Nanosina.Twice a day in the morning and at the night, 12 hours interval, in the anterior of wrist is rubbed. duration of treatment is 8-week.The ointment should not be washed up to 2 hours after using the ointment. Intervention 2: Control group: The placebo is an ointment that has a shape, color and concentration similar to curcumin ointment. The tubes are in the same shape.Produced by Exir Nanosina company.The frequency of use, dose and duration of use is the similar to intervention group. Yes - There is a plan to make this available What will be shared: Only the part of the data about the main of outcome will be shared When: the access period is 6 months after publishing the results To whom: Only for researchers working in academic and scientific institutions Conditions: Only for scientific use Where to obtain: Narges Karimi Email: Drkarimi_236@yahoo.com How to obtain: Noting the reason for requesting and identifying the type of applicant institution Email: Drkarimi_236@yahoo.com After review and, if possible, the data will be sent Comments:
public Narges Karimi
No.47, Mirjani street, Baghsang street, Panzdah khordad street
Sari Iran (Islamic Republic of) 4818734619 +98 11 3311 6275 Drkarimi_236@yahoo.com Mazandaran University of Medical Sciences scientific Narges Karimi
Baran department, Mirjani Street, Panzdah khordad street, Baghsang street,
Sari Iran (Islamic Republic of) 4818734619 +98 11 3311 6275 Drkarimi_236@yahoo.com Mazandaran University of Medical Sciences Iran (Islamic Republic of) Female patients aged 18-65 years old completed the informed consent form Sign and symptoms of carpal tunnel syndrome: at least two symptoms or one symptom and one sign including: pain, paresthesia, hypoesthesia, numbness, positive phalen or tinel test Electrodiagnostic evidence suggestive of mild to moderate idiopathic carpal tunnel syndrome 18 years 65 years Female Positive history of the curcumin hypersensitivity Failure to complete the information collection form Cervical radiculopathy or brachial plexopathy, TOS,Protator teres syndrome, ulnar neuropathy Clinical Signs or Electrodiagnostic evidence of Polyneuropathy Rheumatologic disorders such as: rheumatoid arthritis, systemic sclerosis, Lupus, Amyloidosis and so on Endocrine disorders: Diabetes, hypothyroid Conditions that mimic carpal tunnel syndrome, such as multiple sclerosis Pregnancy and lactation Serious cardiovascular disease like heart failure and kidney disease Intravenous injection or physiotherapy for the treatment of carpal tunnel syndrome over the past 6 months A positive history of a severe trauma or fracture of the wrist The inevitable use of corticosteroids or analgesic drugs Patients with severe carpal tunnel syndrome based on clinical or electrodiagnostic evidence G56.0 Carpal tunnel syndrome Treatment - Drugs Placebo Intervention group: Curcumin topical ointment is a turmeric extract and is manufactured by Exir Nanosina.Twice a day in the morning and at the night, 12 hours interval, in the anterior of wrist is rubbed. duration of treatment is 8-week.The ointment should not be washed up to 2 hours after using the ointment. Control group: The placebo is an ointment that has a shape, color and concentration similar to curcumin ointment. The tubes are in the same shape.Produced by Exir Nanosina company.The frequency of use, dose and duration of use is the similar to intervention group. Boston questionnaire score and severity of pain according to VAS. Timepoint: Before intervention and Eighth week after treatment. Method of measurement: Boston questionnaire and VAS. EMG-NCV parameters changes. Timepoint: Before intervention and Eighth week after treatment. Method of measurement: Electrodiagnostic. Mazandaran University of Medical Sciences Approved 2018-07-08 Ethics committee of Mazandaran University of Medical Sceinces Joibar Three ways, Valiasr blvd, Sari city Sari Mazandaran Iran (Islamic Republic of)