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IRCT20141209020258N97 IRCT 2019-02-22 Arak University of Medical Sciences Comparison of Dexmedetomidine and Lidocaine to cough suppression after anesthesia Comparison of Dexmedetomidine and Lidocaine to cough suppression after anesthesia 2018-09-23 anticipated 102 Complete https://irct.ir/trial/36375 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple individual randomization with random number table in division of groups in two groups A and B. Randomization method: Simple randomization. Random unit: Individual. How to build sequences: First, we set the framework for our statistical society. We started from a table point in a row or column. Given the type of code in the row, we chose the same number of digits. After that, the numbers control the path. We noticed smaller numbers of the statistical community. We have to continue this work so that the number of samples is completed.Even numbers were used for intervention group and odd numbers were used for the control group. Allocation concealment:Numbered drug containers, Blinding description: This study is double blind. Researcher who complete questionnaire and analyzer are blind (double blind).Outcome assessor and analyzer don't aware from grouping.The person evaluating the outcome is unaware of the grouping. Groups A and B are available to analyzer and outcome assessor. 2-3 Patients candidates general anesthesia. Intervention 1: Intervention group1: We infuse 0/5 micro gram in kilogram Dexmedetomidine(PFIZER [America]) in 10 milliliter of volume for 10 minute before extubation in intervention group. Intervention 2: Intervention group 2: We infuse 1/5 milligram in kilogram Lidocaine(Aboreihan Co) in 10 milliliter of volume for 10 minute before extubation in Lidocaine group. Intervention 3: Control group: We infuse 10 milliliter normal saline for 10 minute in placebo group after extubation. Yes - There is a plan to make this available What will be shared: When we publish article in journal When: After the article is published To whom: researcher in university Conditions: If there are additional questions Where to obtain: Dr Modir How to obtain: They have to write letters to the professors and the university Comments:
public dr Bijan Yazdi
Valiasr Hospital, Valiasr squre, Shahid Shirodi street
Arak Iran (Islamic Republic of) 3814957558 +98 86 3222 2003 yazdi@arakmu.ac.ir Arak University of Medical Sciences scientific Dr Hesamedin Modir
Valiasr Hospital, Valiasr squre, Shahid Shirodi street
Arak Iran (Islamic Republic of) 3814957558 +98 86 3222 2003 modir.he@gmail.com Arak University of Medical Sciences Iran (Islamic Republic of) 20 to 60 years old ASA class I and II Mallampathi class I and II no addiction no smoking Non-activated airway infections or history of surgery and pathology of the chest and larynx Lack of inadequacy of the esophagus sphincter (no reflux) body mass index more than 30 Lack of increased Intracranial pressure and intraocular pressure Duration of surgery is between 60 - 120 minutes 20 years 60 years Both Lack of satisfaction of patients Lack of pulmonary and heart disease No use  Medications creates a cough Y48.4 Anaesthetic, unspecified Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group1: We infuse 0/5 micro gram in kilogram Dexmedetomidine(PFIZER [America]) in 10 milliliter of volume for 10 minute before extubation in intervention group. Intervention group 2: We infuse 1/5 milligram in kilogram Lidocaine(Aboreihan Co) in 10 milliliter of volume for 10 minute before extubation in Lidocaine group. Control group: We infuse 10 milliliter normal saline for 10 minute in placebo group after extubation. Cough. Timepoint: Extubation time and Tenth minute and in the recovery until 40 minutes after removing the tracheal tube. Method of measurement: observation. Laryngospasm. Timepoint: Extubation time and Tenth minute and in the recovery until 40 minutes after removing the tracheal tube. Method of measurement: observation. Duration of surgery. Timepoint: after intervention. Method of measurement: minute. Percent of oxygen saturation. Timepoint: Immediately after extubation and then every 5 minutes to 40 minutes after the tube exits. Method of measurement: Pulse oximeter. Blood pressure. Timepoint: Every 10 minutes to 40 minutes after the extubation of the tracheal tube. Method of measurement: Barometer. Heart rate. Timepoint: Every 10 minutes to 40 minutes after the extubation of the tracheal tube. Method of measurement: Count. Arak University of Medical Sciences Approved 2018-09-16 Ethics Committe Arak University Of Medical Sciences Vice President of Research, Payambar Azam Complex, Basij square, Sardasht, Arak Arak Markazi Iran (Islamic Republic of)