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IRCT20110123005670N27 IRCT 2019-02-24 Tabriz University of Medical Sciences Effect of curcumin on systemic inflammatory response syndrome cosirs Effect of curcumin on coagulation factors, anti-inflammatory factor and Simplified Acute Physiology Score ॥ in patients with systemic inflammatory response syndrome 2018-12-26 anticipated 40 Complete https://irct.ir/trial/36384 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive, Randomization description: Using RAS software and random block method, Blinding description: Patients participating in this study will not be aware of the supplementation of curcumin due to low alertness. 3 sepsis/at risk of sepsis. Intervention 1: Intervention group: Two 80-mg capsules of nano-curcumin (Sina Pharmaceutical Company) per day for 10 days. Intervention 2: Control group: entera meal formula (karen company) or blenderized formula (contain rice flour and meat or poultry and tomato or carrot or cucumber and olive oil or corn oil and apple or orange and yoghurt or powdered milk). Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information
public Dr. Ali Tarighat Esfanjani
Faculty of Nutrition, Ghol-Ghasht st,Tabriz,
Tabriz Iran (Islamic Republic of) 5166614711 +98 41 1335 7581 tarighata@tbzmed.ac.ir Tabriz University of Medical Sciences scientific Dr. Ali Tarighat Esfanjani
Faculty of Nutrition, Ghol-Ghasht st,Tabriz,
Tabriz Iran (Islamic Republic of) 5166614711 +98 41 1335 7581 tarighata@tbzmed.ac.ir Tabriz University of Medical Sciences Iran (Islamic Republic of) Critically ill patients with APACHE II score of 15-30 Positive SIRS Age over 18 and under 60 At least 10 days hospitalization in ICU Patients who received enteral nutrition formula 18 years 60 years Both Parenteral feeding Enteral nutrition and gavage formula intolerance Patients expected to die within the next 24 hours HIV positive patients Pregnant and lactating women ileus Immune disorder Diabetes melitus Short bowel syndrome Pancreatitis R65.1 Systemic inflammatory response syndrome (SIRS) of non-infectious origin Treatment - Drugs N/A Intervention group: Two 80-mg capsules of nano-curcumin (Sina Pharmaceutical Company) per day for 10 days Control group: entera meal formula (karen company) or blenderized formula (contain rice flour and meat or poultry and tomato or carrot or cucumber and olive oil or corn oil and apple or orange and yoghurt or powdered milk) Protein C. Timepoint: Day 1, 5 and 10 of intervention. Method of measurement: ELISA Kit. Partial Thromboplastin time. Timepoint: Day 1, 5 and 10 of intervention. Method of measurement: ELISA kit. Prediction of death. Timepoint: Day 1, 5 and 10 of intervention. Method of measurement: Simplified Acute Physiology Score questionnaire. Transforming growth factor β1. Timepoint: Day 1, 5 and 10 of intervention. Method of measurement: ELISA kit. Deputy of Research and Technology of Tabriz University of Medical Sciences Approved 2018-12-24 Ethics Committee of Tabriz University of Medical Sciences Tabriz University of Medical Sciences, Golgasht street, Tabriz Tabriz East Azarbaijan Iran (Islamic Republic of)