IRCT20150716023235N14 IRCT 2019-01-14 Mashhad University of Medical Sciences The evaluation of Probiotic lactocare effect on patients with parennial allergic rhinitis The evaluation of Probiotic lactocare effect on immune responses and clinical manifestation in patients with parennial allergic rhinitis 2019-02-09 anticipated 30 Complete https://irct.ir/trial/36398 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Basic scienece, Randomization description: Method of block randomization Unit of randomization individual Tools used in randomization computer softwares, Blinding description: Participants will receive the same drug or placebo The main researcher is unaware of the effect of the drug on improving quality of life and effective immune responses. 2 Allergic rhinitis. Intervention 1: Intervention group:In addition to the usual treatments for allergic rhinitis, Steroids nasal spray Rhinocort, a lactocare probiotic daily that contains strains: lactobacillus casei, lactobacillus acidophilus, lactobacillus rhamnosus, lactobacillus bolgaricus, bifidobacterium bereve, bifidobacterium longum, stereptococus thermophilus is prescribed.The duration of the intervention is 6 months.  probiotic lactocare from the Zist Takhmir company is Iran. Intervention 2: Control group:In addition to the usual treatments, Steroids nasal spray Rhinocort,a placebo is prescribed daily.The duration of the intervention is 6 months . The placebo from the Zist Takhmir company is Iran. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information