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IRCT20160430027677N13 IRCT 2019-02-24 Oroumia University of Medical Sciences Evaluation the effect of dexmedetomidine and remifentanil on posoperative pain Comparison the effect of dexmedetomidine with remifentanil on postoperative pain after lumbar laminecthomy with general anesthesia 2018-01-20 anticipated 60 Complete https://irct.ir/trial/36414 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients will be randomly assigned into two groups of Dexmedetomidine (group D) and Remifentanil (group R) using Random Allocation Software 2.0, and the target codes will be written and placed in sealed envelopes with sequential allocation using double-blind method, Blinding description: The anesthesiologist will be unaware of which patient will be assigned to which group. Syringes will be identical and only the nurse will knew about the contents of each of them, and finally, after collecting information from the anesthesia residents, the anesthesiologist will be informed of the group each patient will be assigned to. 2-3 pain. Intervention 1: Intervention group:Before anesthesia induction, 0.3 μg/50kg/min dexmedetomidine will be injected using a syringe pump for 10 minutes. During surgery 0.01-0.02 μg/kg/min dexmedetomidine will be used. Intervention 2: Intervention group: Before anesthesia induction, 0.01 μg/kg/min remifentanil will be injected using a syringe pump for 10 minutes. During surgery 0.01to 0.2 μg/kg/min remifentanil will be used. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information
public Shahryar Sane
Emergrnt Street, Resalat Blvd
Urmia Iran (Islamic Republic of) 5714783734 +98 44 3223 4897 sanesh@umsu.ac.ir Oroumia University of Medical Sciences scientific Shahryar Sane
Emergrnt Street, Resalat Boulevard
Urmia Iran (Islamic Republic of) 5714783734 +98 44 3223 4897 sanesh@umsu.ac.ir Oroumia University of Medical Sciences Iran (Islamic Republic of) age group of 20-60 years old American Society of Anesthesiologists class I and II elective lumbar laminectomy 20 years 60 years Both Patients with hypertension History of heart disease Bradycardia (Heart rate less than 50 per minute) arrhythmia People who have allergies to drugs used Gastritis Renal and pulmonary disease mental health problems Drug addict Patients treated with beta-blockers, methyl dopa, monoamine oxidase inhibitors Pain medications Body mass index greater than 25 kg/ m2 R52.9 Generalized pain NOS Treatment - Drugs Treatment - Drugs Intervention group:Before anesthesia induction, 0.3 μg/50kg/min dexmedetomidine will be injected using a syringe pump for 10 minutes. During surgery 0.01-0.02 μg/kg/min dexmedetomidine will be used. Intervention group: Before anesthesia induction, 0.01 μg/kg/min remifentanil will be injected using a syringe pump for 10 minutes. During surgery 0.01to 0.2 μg/kg/min remifentanil will be used. Pain. Timepoint: In recovery, 6, 12 and 24 hours after surgery. Method of measurement: Visual Analogue Scale. The average need for an analgesic drug to control pain. Timepoint: In 12 hours after surgery. Method of measurement: milligram. Mean Arterial Blood Pressure. Timepoint: time of laryngoscopy and during surgery. Method of measurement: None Invasive Blood Pressure. Mean pulse Rate. Timepoint: time of laryngoscopy and during surgery. Method of measurement: Electrocardiogram. Oroumia University of Medical Sciences Approved 2017-12-13 Ethics commitee of Urmia University of Medical Sciences Emergent Street, Ershad Avenue Urmia West Azarbaijan Iran (Islamic Republic of)