IRCT201409133549N7 IRCT 2014-10-20 Vice - Chancellery for Research, Zahedan University of Medical sciences Impact of mouthwashes on Mucositis Comparison of effect of topical utilization of Honey and Chamomile for Prevention on Chemotherapy-induced Mucositis in Children with Leukemia 2014-05-20 anticipated 40 Complete https://irct.ir/trial/3642 interventional Randomization: Not randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Other design features: Single blind means that researcher is not aware from type of mouthwash which is given to each patient. Each patient who comes to the study is selected by the nurse of the department and is allocated to one of the groups (interventions, positive or negative controls). Mouthwash is administered to them while the researcher is not aware from the type of mouthwash. 3 Mucositis induced by Chemotherapy in children with Leukemia. Intervention 1: Honey diluted to a concentration of 12/5%, every two hours during waking hours for 14 days. Intervention 2: Chamomile Mouthwash , Baryj Essence, Kerman, Iran, every two hours during waking hours for 14 days. Intervention 3: Positive control, Chlorhexidine, ShahrDaruo, Tehran, Iran, every two hours during waking hours for 14 days. Intervention 4: Negative control, Normal saline, Samen, Mashhad, Iran, every two hours during waking hours for 14 days.