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IRCT20101211005363N12 IRCT 2019-04-29 Zanjan University of Medical Sciences Evaluation of pressure- and volume-controlled ventilation on internal jugular vein collapsibility index in hypovolemic patients. Evaluation of pressure- and volume-controlled ventilation on internal jugular vein collapsibility index as a predictor of fluid responsiveness in hypovolemic mechanically ventilated patients in intensive care unit. 2018-09-23 anticipated 60 Complete https://irct.ir/trial/36609 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Diagnostic, Randomization description: The patients will be allocated to 1 of the 2 groups according to a randomization code list by a computer program, Blinding description: In this study, patients are not aware of the treatment group due to the decreased level of consciousness. The researcher who studies the variables, does not know the group of study and change of ventilator setting is done by another person. N/A Hypovolemia. Intervention 1: Intervention group: The patients will be placed on the ventilator under the following conditions. CMV: TV= 8 cc/Kg, PEEP=5, Fio2=50%, and the internal jugular colapsibility index will be measured before and after fluid therapy. Intervention 2: Intervention group: The patients will be placed on the ventilator under the following conditions. PCV and inspiratory pressure will be adjusted so that the tidal volume will be kept at 8 cc / Kg and the current volume does not exceed 900 Cc and the maximum pressure will be less than 30 centimeters of water. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information
public sajad Mohammadi
Gavazang Road, Mosavie Hospital
Zanjan Iran (Islamic Republic of) 4513994945 +98 24 3313 1559 sajad.mohammadi.6182@gmail.com Zanjan University of Medical Sciences scientific Taraneh Naghibi
Mosavi Hospital, Gavazang Road
Zanjan Iran (Islamic Republic of) 4513994945 +98 243313559 tnaghibi@zums.ac.ir Zanjan University of Medical Sciences Iran (Islamic Republic of) Hypovolemic patients Age over 18 years 18 years no limit Both Cardiovascular and pulmonary diseases Sepsis Neck collar or neck dressing E86.1 Hypovolemia Diagnosis Diagnosis Intervention group: The patients will be placed on the ventilator under the following conditions. CMV: TV= 8 cc/Kg, PEEP=5, Fio2=50%, and the internal jugular colapsibility index will be measured before and after fluid therapy. Intervention group: The patients will be placed on the ventilator under the following conditions. PCV and inspiratory pressure will be adjusted so that the tidal volume will be kept at 8 cc / Kg and the current volume does not exceed 900 Cc and the maximum pressure will be less than 30 centimeters of water. Internal jugular collapsibility index in volume mode before fluid therapy. Timepoint: 5 minutes after selecting the volume mode. Method of measurement: ultrasound system (eZono 3000). Internal jugular collapsibility index in pressure mode before fluid therapy. Timepoint: 5 minutes after selecting the pressure mode. Method of measurement: ultrasound system (eZono 3000). Internal jugular collapsibility index in volume mode after fluid therapy. Timepoint: 5 minutes after fluid therapy. Method of measurement: ultrasound system (eZono 3000). Internal jugular collapsibility index in pressure mode after fluid therapy. Timepoint: 5 minutes after fluid therapy. Method of measurement: ultrasound system (eZono 3000). Zanjan University of Medical Sciences Approved 2017-10-16 Ethics committee of Zanjan University of Medical Sciences Office of Vice- Chancellor for Research, Zanjan University of Medical Sciences, Azadi square Zanjan Zanjan Iran (Islamic Republic of)