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IRCT201307133566N2 IRCT 2013-08-03 Tabriz university of medical sciences, assistance research Effect of dapson in treatment of pemphigus vulgaris Evaluation of therapeutic effect of prednisolone + dapson with prednisolone+imurane in pemphigus vulgaris treatment 2012-09-19 anticipated 30 Complete https://irct.ir/trial/3666 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2-3 Pemphigus vulgaris. Intervention 1: control: treatment by prednisolone+imurane prednisolone 1-2mg/kg/day imurane:2-3mg/kg/day. Intervention 2: Interventionaris treatment by prednisolone + dapson prednisolone 1-2mg/kg /day dapson100-200mg/day.
public Dr. Hamide Azimi
Sina hospital, Azadi avenue
Tabriz Iran (Islamic Republic of) 5163639888 +98 41 1540 6612 azimi@tbzmed.ac.ir Tabriz university of medical sciences scientific Dr. Hamide Azimi
Sina hospital, Azadi avenue
Tabriz Iran (Islamic Republic of) 5163639888 +98 41 1540 6612 azimi@tbzmed.ac.ir Tabriz university of medical sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Inclusion criterion: patients with pemphigus vulgaris, that their disease was detected by the clinical or pathological evidence of initial tests with pemphigus vulgaris. Exclusion criterion: patients who were G6PDD. no limit no limit Both L10.0 Pemphigus vulgaris Treatment - Drugs Treatment - Drugs control: treatment by prednisolone+imurane prednisolone 1-2mg/kg/day imurane:2-3mg/kg/day Interventionaris treatment by prednisolone + dapson prednisolone 1-2mg/kg /day dapson100-200mg/day Severity of damage. Timepoint: The patients for eleven months and at weeks zero, one, two, three, and four, two months later, three months later, fiv months later e, seven months later, nine months later and eleven months later of treatment follow up. Method of measurement: Physical examination. Lipid profile. Timepoint: The patients for eleven months and at weeks zero, one, two, three, and four, two months later, three months later, fiv months later e, seven months later, nine months later and eleven months later of treatment follow up. Method of measurement: Lab tests. HTN. Timepoint: the patients for eleven months and at weeks zero, one, two, three, and four, two months later, three months later, fiv months later e, seven months later, nine months later and eleven months later of treatment follow up. Method of measurement: lab. Liver function test. Timepoint: The patients for eleven months and at weeks zero, one, two, three, and four, two months later, three months later, fiv months later e, seven months later, nine months later and eleven months later of treatment follow up. Method of measurement: Lab tests. Tabriz university of medical sciences, assistance research Approved 2012-09-15 Tabriz university of medical sciences azady avenue,golgasht avenue tabriz Iran (Islamic Republic of)