Purpose: In this study we Compare lidocaine gel and
methoxyflurane in relieving pain in patients scheduled to
undergo elective cystoscopy.
Method: After obtaining informed and written consent and permission, 60 patients between the ages of 20 and 55 years undergoing a cystoscopy procedure enrolled in this interventional non-blind clinical study.
Exclusion criteria: Allergy to lidocaine and methoxyflurane, concurrent use of analgesics in recent 24 hours, age>55 years old, addiction, renal failure, neuropathy, liver disease, pregnancy.
Patient were randomly allocated to two groups, that one of them received methoxyflurane 5 minutes before cystoscop entrance and another was administered lidocaine 2% gel 15 minutes before procedure then were evaluated and compared heart rate, blood pressure, oxygen saturation and pain (utilizing visual analog scale) before entrance, at the time of drug administration, just at the instrument insertion, during bladder examination, end of procedure and 15 minutes after operation. Method
of randomization is computer generated.
Whenever during study; if patient had pain with score more than 4 based in visual analog scale, should be administered alfentanyl 10 microgram/kg. We compare dose of administered alfentanyl between two groups. After 2 weeks we will measure alanine transaminase, aspartate transaminase, alkaline phosphatase, creatinine, blood urea nitrogen and urine analysis of the patients.