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IRCT201207253579N3 IRCT 2012-12-12 Vice chancellor for research, Shahid Beheshti University of Medical Sciences Comparison of lidocaine gel and methoxyflurane in cystoscopy Comparison of lidocaine gel and methoxyflurane in relieving pain in patients scheduled to undergo elective cystoscopy 2012-12-15 anticipated 60 Complete https://irct.ir/trial/3682 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention. 2 Analgesic effect of methoxyflurane and lidocaine gel during cystoscopy. Intervention 1: Methoxyflurane is a volatile fluorinated hydrocarbon anesthetic agent that is available with 3 CC ampoules to be used in a penthrox inhaler. The inhaler is primed with 3 CC methoxyflurane. The inhaler dispenses 0.2-0.4% with the dilutor hole open and 0.5-0.7% with it closed. The device contains an oxygen port. We used penthrox inhaler for administration of methoxyflurane with activated charcoal scavenging chamber. We asked the patient to close the dilutor hole with his finger and put the inhaler mouth piece in the mouth and exhale through the mouth piece or the nose. For each patient we used maximum one vial (3cc) without oxygen. No more than two patients are to be administered methoxyflurane per shift. Each inhaler is just for one patient. Intervention 2: Fifteen minutes before the procedure 20 cc lidocaine gel 2% is administered. Intervention 3: In each step of the study if pain score is more than 4 (utilizing VAS) we will administer 10 microgram/kg alfentanyl.
public Hasti Hassani
Ninth Boostan Ave., Pasdaran St.
Tehran Iran (Islamic Republic of) 1666694515 +98 21 2254 9029 hasti62h@yahoo.com Shahid Beheshti University of Medical Sciences scientific Alireza Jafari
Ninth Boostan Ave., Pasdaran St.
Tehran Iran (Islamic Republic of) 1666694515 +98 21 2254 9029 alirezjaffari@sbmu.ac.ir Shahid Beheshti University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: patients with American Society of Anesthesiologists Physical Status Classification (ASA class) I and II scheduled to undergo elective cystoscopy and their age is between 20-55 years old. Exclusion criteria: Allergy to lidocaine and methoxyflurane, concurrent use of analgesics in recent 24 hours, age>55 years old, addiction, renal failure, neuropathy, liver disease, pregnancy. 20 years 55 years Male y.48.0 y.4 Inhaled anesthetics local anesthetics Prevention Prevention Treatment - Drugs Methoxyflurane is a volatile fluorinated hydrocarbon anesthetic agent that is available with 3 CC ampoules to be used in a penthrox inhaler. The inhaler is primed with 3 CC methoxyflurane. The inhaler dispenses 0.2-0.4% with the dilutor hole open and 0.5-0.7% with it closed. The device contains an oxygen port. We used penthrox inhaler for administration of methoxyflurane with activated charcoal scavenging chamber. We asked the patient to close the dilutor hole with his finger and put the inhaler mouth piece in the mouth and exhale through the mouth piece or the nose. For each patient we used maximum one vial (3cc) without oxygen. No more than two patients are to be administered methoxyflurane per shift. Each inhaler is just for one patient. Fifteen minutes before the procedure 20 cc lidocaine gel 2% is administered. In each step of the study if pain score is more than 4 (utilizing VAS) we will administer 10 microgram/kg alfentanyl. Pain. Timepoint: Before entrance, at the time of drug administration, just at the instrument insertion, during bladder examination, end of procedure and 15 minutes after operation. Method of measurement: standard visual analog scale. Heart rate. Timepoint: Before entrance, at the time of drug administration, just at the instrument insertion, during bladder examination, end of procedure and 15 minutes after operation. Method of measurement: Electrocardiography monitoring. Blood pressure. Timepoint: Before entrance, at the time of drug administration, just at the instrument insertion, during bladder examination, end of procedure and 15 minutes after operation. Method of measurement: Noninvasive blood pressure. Blood oxygen saturation. Timepoint: Before entrance, at the time of drug administration, just at the instrument insertion, during bladder examination, end of procedure and 15 minutes after operation. Method of measurement: Pulse Oxymetry. Vice chancellor for research, Shahid Beheshti University of Medical Sciences Approved 2012-03-12 Urology ethic committee of Shahid Beheshti University of Medical Sciences Ninth Boostan Ave., Pasdaran St. Tehran Iran (Islamic Republic of)