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IRCT20170527034146N2 IRCT 2019-02-18 Ghoum University of Medical Sciences Evaluation of the occurrence, effect and side effects oFcyclophosfamid and rituximab in the tratment of children with NEPHROTIC SYNDROM resistance to STEROID that referred to Hazrate Massumeh hospital . Evaluation of the occurrence, effect and side effects oFcyclophosfamid and rituximab in the tratment of children with NEPHROTIC SYNDROM resistance to STEROID that referred to Hazrate Massumeh hospital . 2017-09-23 anticipated 102 Complete https://irct.ir/trial/37066 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: The simple random sampling method was used for the selected sample and was divided into two groups of intervention and control by simple randomized distribution method. The randomized random number tool is the unit of individual cadastre. The patients were divided into two equal groups, regardless of sex and age, and on the basis of resistant to steroid therapy.The intervention group, in addition to prednisolone, received Ritoximab, which received a cyclophosphamide drug control group. 2 Nephrotic syndrome resistance to steroide. Intervention 1: Intervention group:I ntervention group: In addition to prednisolone, ritoximab with 375 mg / m 2 / day was given intravenously and weekly for 4 weeks. Intervention 2: Control group: Control group: In addition to prednisolone, cyclosfamide dose of 2 mg per kg per day For three months. Yes - There is a plan to make this available What will be shared: Some of the details, such as information about the original message or its lover, can be shared. When: Since 1399 To whom: Researchers working in academia and academia Conditions: Clinical analyzes and clinical findings Where to obtain: Principal Principal Prose Mohsen Akhavan Sepahi. E-mail: makhavan@muq.ac.ir How to obtain: Apply by e-mail to Mohsen Akhavan Sepahi Comments:
public Mohsen Akhavan sepahi
Emam sereet
Qom Iran (Islamic Republic of) 3719815532 +98 25 3665 1804 makhavan@muq.ac.ir Ghoum University of Medical Sciences scientific Mohsen Akhavan sepahi
Emam street
Qom Iran (Islamic Republic of) 3719815532 +98 256651804 makhavan@muq.ac.ir Ghoum University of Medical Sciences Iran (Islamic Republic of) َAll patient whit nephrotic syndrome resistance to steroid whit age 1-18 yr 1 year 18 years Both All patient who do not have steroid-resistant Nephrotic Syndrome for example patient with steroids depended syndrome. All patient who did not accept treatment All patient who died All patient who did not follow up N04.8 Nephrotic syndrome with other morphologic changes Treatment - Drugs Treatment - Drugs Intervention group:I ntervention group: In addition to prednisolone, ritoximab with 375 mg / m 2 / day was given intravenously and weekly for 4 weeks. Control group: Control group: In addition to prednisolone, cyclosfamide dose of 2 mg per kg per day For three months The frequency of relapse of the disease before and after taking the cyclofosfamide and ritoximab. Timepoint: Weekly. Method of measurement: Urin analysis of proteine. Dosage of the prednisolon before and after taking the medication. Timepoint: weekly. Method of measurement: check liste. Number of relapses after receiving rutioxime and cyclolophosphamide. Timepoint: weekly. Method of measurement: Urinalysis. Patient's disease. Dosage of Steroids after receiving medication. Timepoint: weekly. Method of measurement: check liste. Assistant research in Qom medical univercity Ghoum University of Medical Sciences Assistant research in Qom medical univercity Approved 2017-09-05 Ethics committee of QOM University of Medical Sciences EMAM STREET. QOM Ghoum Iran (Islamic Republic of)