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IRCT20190128042529N1 IRCT 2019-02-21 Vice Chancellor of Research Ferdowsi University of Mashhad The effect of exercise on type 2 diabetes The effect of twelve weeks combined exercise training on insulin resistance and some metabolic factors in type II diabetic patients 2018-04-09 anticipated 90 Complete https://irct.ir/trial/37207 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: Randomization will be performed by the SAS software and every patient will be entered in the exercise 1, exercise 2 or control group. N/A Type II diabetes mellitus. Intervention 1: The first intervention group: The aerobic-resistance group will exercise for 12 weeks and three sessions a week. The aerobic-resistance group will perform the aerobic protocol and then the resistance protocol during a training session. The aerobic exercise protocol is 1×10 minutes exercise with one minute active rest between the sets (with using treadmill). Resistance exercises include movements such as leg press, bench press, seated leg extension, lat pull down, lying leg curl, seated shoulder press, which there are include the main muscles of the lower trunk and upper trunk and they will be done by the machine. Intervention 2: The second intervention group: The resistance-aerobic group will exercise for 12 weeks and three sessions a week. The resistance-aerobic group will perform the resistance protocol and then the aerobic protocol during a training session. The aerobic exercise protocol is 1×10 minutes exercise with one minute active rest between the sets (with using treadmill). Resistance exercises include movements such as leg press, bench press, seated leg extension, lat pull down, lying leg curl, seated shoulder press, which there are include the main muscles of the lower trunk and upper trunk and they will be done by the machine. Intervention 3: Control group: community-based and untrained. Yes - There is a plan to make this available What will be shared: The whole data is potentially shared after unidentified individuals. When: The beginning of the data access period is 6 months after the publication of the articles. To whom: The data will be accessible only to researchers working in academic institutions. Conditions: All analyzes and all data Where to obtain: To receive research information, send an email to Reihane.nejati@gmail.com. How to obtain: Data will be sent after obtaining permission from the project manager. Comments:
public Seyyed Reza Attarzadeh Hosseini
Ferdowsi University of Mashhad, Azadi Square.
Mashhad Iran (Islamic Republic of) 9177948974 +98 51 3883 3910 attarzadeh@um.ac.ir Ferdowsi University of Mashhad scientific Seyyed Reza Attarzadeh Hosseini
Ferdowsi University of Mashhad, Azadi Square.
Mashhad Iran (Islamic Republic of) 9177948974 +98 51 3883 3910 attarzadeh@um.ac.ir Ferdowsi University of Mashhad Iran (Islamic Republic of) Confirmation of Type 2 Diabetes (Fasting blood glucose greater than 126 mg/dL, Oral glucose tolerance test equal to or greater than 200 mg/dL, A1C level of 6.5 percent or higher) BMI 28-35 Age between 40-50 years 40 years 50 years Both use insulin having  cardiovascular diseases, musculoskeletal disorders, liver disease, kidney disease, thyroid dysfunction having regular physical activity in at least the last six months Prevention Prevention Prevention The first intervention group: The aerobic-resistance group will exercise for 12 weeks and three sessions a week. The aerobic-resistance group will perform the aerobic protocol and then the resistance protocol during a training session. The aerobic exercise protocol is 1×10 minutes exercise with one minute active rest between the sets (with using treadmill). Resistance exercises include movements such as leg press, bench press, seated leg extension, lat pull down, lying leg curl, seated shoulder press, which there are include the main muscles of the lower trunk and upper trunk and they will be done by the machine. The second intervention group: The resistance-aerobic group will exercise for 12 weeks and three sessions a week. The resistance-aerobic group will perform the resistance protocol and then the aerobic protocol during a training session. The aerobic exercise protocol is 1×10 minutes exercise with one minute active rest between the sets (with using treadmill). Resistance exercises include movements such as leg press, bench press, seated leg extension, lat pull down, lying leg curl, seated shoulder press, which there are include the main muscles of the lower trunk and upper trunk and they will be done by the machine. Control group: community-based and untrained. Insulin resistance. Timepoint: Before the intervention and 48 hours after the end of intervention. Method of measurement: HOMA-IR method. Glucagon-like peptide-1 (GLP-1). Timepoint: Before the intervention and 48 hours after the end of intervention. Method of measurement: ELISA method. HbA1C. Timepoint: Before the intervention and 48 hours after the end of intervention. Method of measurement: Nyco Card device. ALP. Timepoint: Before the intervention and 48 hours after the end of intervention. Method of measurement: spectrophotometry method. Aspartate aminotransferase (SGOT or AST). Timepoint: Before the intervention and 48 hours after the end of intervention. Method of measurement: spectrophotometry method. Alanine aminotransferase (SGPT or ALT). Timepoint: Before the intervention and 48 hours after the end of intervention. Method of measurement: spectrophotometry method. Vice Chancellor of Research Ferdowsi University of Mashhad Approved 2018-04-19 Ferdowsi University of Mashhad Ferdowsi University of Mashhad, Azadi square Mashhad Razavi Khorasan Iran (Islamic Republic of) Approved 2018-09-22 Mashhad University of Medical Sciences Mashhad University of Medical Sciences, Azadi square. Mashhad Razavi Khorasan Iran (Islamic Republic of)