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IRCT20121229011923N6 IRCT 2019-02-18 Shoushtar University of Medical Sciences Comparison of the efficacy of Clonidine and Tranexamic Acid on the volume of bleeding during rhinoplasty under general anesthesia: clinical trial Comparison of the efficacy of Clonidine and Tranexamic Acid on the volume of bleeding during rhinoplasty under general anesthesia: clinical trial 2019-02-20 anticipated 135 Complete https://irct.ir/trial/37254 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: 135 people will be selected based on the formula for comparison of the meanings and randomly divided randomly into two groups of case (90) and a control group (45 people) based on the randomized quadruple randomization method. Then, the patients in the case group will be divided into two groups of Clonidine and Tranexamic Acid (45) and (45) by the reviewer, who will code the groups, Blinding description: In this study, the patients and the ENT surgeon will be unaware of the patient's group and the drugs. Only the investigator responsible for the study who is involved in the classification of the patients is aware. 3 Evaluation of bleeding during nasal surgery. Intervention 1: First intervention group: clonidine 3 micrograms per kilogram will be given orally 90 minutes before the surgery, and the amount of bleeding will be examined during surgery. Intervention 2: Second intervention group: Tranexamic Acid capsule 250 micrograms per kilogram body weight will be given to patients twice a day before surgery and the volume of bleeding will be examined during surgery. Intervention 3: Control group: The amount of bleeding will be checked without clonidine and Tranexamic Acid medications. Yes - There is a plan to make this available What will be shared: I do not know When: I do not know To whom: I do not know Conditions: I do not know Where to obtain: I do not know How to obtain: I do not know Comments:
public Akram Hemmatipour
Shoushtar University of Medical Sciences, West Rajaee Crossroads
Shoushtar Iran (Islamic Republic of) 6451984381 +98 61 3622 2221 hematipour.a64@gmail.com Shoushtar University of Medical Sciences scientific Akram Hemmatipour
Shoushtar University of Medical Sciences, West Rajaee Crossroads
Shoushtar Iran (Islamic Republic of) 6451984381 +98 61 3622 2221 hematipour.a64@gmail.com Shoushtar University of Medical Sciences Iran (Islamic Republic of) Conscious willingness to participate in research Age between 18-60 years Classification of the American Society of Anesthesiology in Class I and II: Class 1: includes patients with normal health who have no systemic problems, such as cardiovascular, respiratory, gastrointestinal, etc. Class 2: Includes a person with mild systemic disease and disease Is under control and has not caused any limitation for the patient) 18 years 60 years Both Drug addiction, benzodiazepines, liver and kidney failure, diabetes, pulmonary and heart disease, coagulation disorders; History of hypersensitivity to clonidine and Tranexamic Acid (increased blood pressure) Y44.2 Anticoagulants Treatment - Drugs Treatment - Drugs Treatment - Drugs First intervention group: clonidine 3 micrograms per kilogram will be given orally 90 minutes before the surgery, and the amount of bleeding will be examined during surgery. Second intervention group: Tranexamic Acid capsule 250 micrograms per kilogram body weight will be given to patients twice a day before surgery and the volume of bleeding will be examined during surgery. Control group: The amount of bleeding will be checked without clonidine and Tranexamic Acid medications. Evaluation of bleeding during nasal surgery. Timepoint: During and after nose surgery. Method of measurement: The size of the bleeding will be calculated based on the amount of bleeding accumulated in the suction and the blood-stained gases that will be weighed and the surgeon's vision. Shoushtar University of Medical Sciences Approved 2019-01-14 Ethics Committee of Shoushtar University of Medical Sciences Shoushtar University of Medical Sciences, West Rajaee Crossroads Shoushtar Khouzestan Iran (Islamic Republic of)