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IRCT20120909010795N3 IRCT 2019-05-09 Shiraz University of Medical Sciences Comparison of pentoxifylline and tacrolimus in the treatment of vitiligo patients comparing the additive effect of topical pentoxifylline and phototherapy versus topical tacrolimus and phototherapy inpateints with vitiligo 2017-08-23 anticipated 35 Complete https://irct.ir/trial/37367 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization tool, random number table, Blinding description: Patients were enrolled with informed consent. The two drugs used in patients were in the same boxes. The drugs were marked with a code and they had the same shape. The prescriber was not aware of the drug encoding. For each patient, two lesions have been selected at two points in his body. patients did not know the coding of drugs. The treating physician who visited them in three steps did not know the encoding of drugs. The analyzer did not know the coding of the drugs. The author of the draft article did not know the encoding of drugs. The drug code was only available to the manufacturer of the drug, which has been available to other researchers after writing the draft article. 3 vitiligo. Intervention 1: Intervention group: 35 vitiligo lesions have been treated locally with pentoxifylline in patients with NBUVB treated light therapy. Pentoxifylline was 10% in the form of a topical cream. This drug was made by the Faculty of Pharmacy of Shiraz University of Medical Sciences. The method of making drug was incorporation on the basis of cold cream . Intervention 2: Control group: 35 Vitiligo lesions have been treated topically with tacrolimus in patients with NBUVB treated light therapy. Tacrolimus is a topical cream of 0.1%. This drug is made by aburaihan pharmaceutical Co, a brand name of moduproc. Yes - There is a plan to make this available What will be shared: Information on the outcome of the disease is sharing. When: 3 months after the publication of results To whom: Researchers working in academic and scientific institutions Conditions: To conduct similar clinical trials Where to obtain: Electronic correspondence with research officer How to obtain: By emailing the corresponder researcher or telephone, within a period of one month, research documentation will be available. Comments:
public Nasrin Saki
dermatology ward, shahid faghihi hospital, zand Blvd
shiraz Iran (Islamic Republic of) 7134846114 +98 71 3231 9049 sakina@sums.ac.ir Shiraz University of Medical Sciences scientific nasrin saki
dermatology ward, shahid faghihi hospital, zand Blvd
shiraz Iran (Islamic Republic of) 7134846114 +98 71 3231 9049 sakina@sums.ac.ir Shiraz University of Medical Sciences Iran (Islamic Republic of) Patients with vitiligo (with clinical diagnosis and Wood's Lamp) Patients with at least two relatively and bilateral lesion. Patients undergoing treatment with NBUVB Residence in Shiraz, in case of non-residence in Shiraz, may attend meetings required for a visit. Having the ability to understand Persian language written consent to participate in the study. 14 years 70 years Both Over the last three months, they have received topical vitiligo medication Unwillingness to receive local interventions L80 Vitiligo Treatment - Drugs Treatment - Drugs Intervention group: 35 vitiligo lesions have been treated locally with pentoxifylline in patients with NBUVB treated light therapy. Pentoxifylline was 10% in the form of a topical cream. This drug was made by the Faculty of Pharmacy of Shiraz University of Medical Sciences. The method of making drug was incorporation on the basis of cold cream . Control group: 35 Vitiligo lesions have been treated topically with tacrolimus in patients with NBUVB treated light therapy. Tacrolimus is a topical cream of 0.1%. This drug is made by aburaihan pharmaceutical Co, a brand name of moduproc. Pigmentation. Timepoint: At the beginning of the study, one month and three months after starting treatment. Method of measurement: Qualitative measure with VASI score and quantitative measurement with dermocatch tool. Shiraz University of Medical Sciences Approved 2017-08-23 Ethics committee of Shiraz University of Medical Sciences shahid faghihi hospital, zand Blvd shiraz Fars Iran (Islamic Republic of)