IRCT20190206042639N1 IRCT 2019-09-24 Tehran University of Medical Sciences The comparison between intravenous acetaminophen versus oral ibuprofen in preterm newborns with patent ductus arteriosus The comparison between intravenous acetaminophen versus oral ibuprofen in preterm newborns with patent ductus arteriosus 2016-06-21 anticipated 80 Complete https://irct.ir/trial/37441 interventional Randomization: Not randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: Oral ibuprofen is a commonly used drug for treating PDA in premature infants in Iran.Contraindications for use in premature infants admitted to the NICU are abundant.The particular feature of our study was that we used intravenous acetaminophen (apotel) for patients who were contraindicated in taking ibuprofen and having a hemodinamicaly significant PDA. Therefore, patients who were normally deprived of treatment were treated with intravenous acetaminophen, Blinding description: Participants (premature infants) have no information about prescribing drugs. The data analyzer has no information about type of Prescribing drugs. Safety Committee and Data Supervision has no information about type of Prescribing drugs. 3 Patent Ductus Arteriosus. Intervention 1: Intervention group: Oral ibuprofen with a dose of 10 mg per kg on the first day and then 5 mg per kilogram in the next two doses at intervals of 24 and 48 hours. Intervention 2: Intervention group: Intravenous Acetaminophen With a dose of 10 mg per kg body weight every 6 hours up to a maximum of 60 mg per kg per day for 3 days. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is So far, I have not decided on this, but I plan to provide a suitable program for its release.