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IRCT20181031041519N2 IRCT 2019-06-10 Tehran University of Medical Sciences Comparison the use of dyrogesterone and steroid in IVF Cycles. A comparative study of the use of dydrogesterone and GnRH antagonists in InVitro Fertilization (IVF) cycles. 2019-06-05 anticipated 200 Complete https://irct.ir/trial/37495 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: A random method using a random numbers table which the researcher selects to read the numbers from top to bottom and on one of the numbers she places her finger and moves up and down and records the numbers that consider the pair numbers for the intervention group (A) and the individual numbers for the control group (B). 3 Female infertility. Intervention 1: Intervention group: Group A (study group): On the second day of the menstrual cycle, all patients undergo vaginal sonography, and in the absence of follicles greater than 10 mm, the treatment cycle begins. Patients receive oral progesterone or dydrogesterone (Duphaston, 20 mg daily, oral). Six days after the start of treatment, vaginal sonography will be performed. At the same time as starting dydrogesterone (2-3 cycles a day), hMG (225-150 units injected daily) is prescribed. In case of appearance, 2 follicles of 18 mm and 3 follicles of 14-15 mm in ultrasound, for the trigger, decapeptide, will be administered at 0.2 cc. It is worth mentioning that taking dydrogesterone is stopped on the trigger day. Intervention 2: Control group: Group B (control): hMG 225-150 injectable units daily) received in 2-3 cycles of menstruation and after administration of hMG, when the follicle reached 13 mm, the Cetrotide antagonist (GnRh, 0.25 mg), It is injected subcutaneously every 24 hours. In case of appearance, 2 follicles of 18 mm and 3 follicles in 14-15 mm in ultrasound, for a trigger, decapeptide, will be prescribed to 0.2 cc. And the antagonist (steroid) injection stops. 36-39 hours after decapeptide injection, ovule collection (OPU, Ovum Pick up) will be done in both groups. n (OPU, Ovum Pick up) will be done in both groups. The ovum obtained is categorized in terms of growth by the embryologist. And 2-3 days after the ICSI, embryos are graded by the number of cells and fragmentation by the specialist. In the next cycle, then in each patient, 2 embryos will be transmitted from the best embryos of good quality (embryos with high blastomeres and without fragmentation) and the embryo transfer will be carried out by one person from the infertility fellowship without knowledge of the patient groups. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information.
public Seyede Masoumeh Ghazi Mirsaeed
Infertility Clinic,Vali Asr Hospital, ImamKhomeini Hospital Complex, Keshavarz Blvd
Tehran Iran (Islamic Republic of) 14194 +98 21 6693 9320 dr_ghazi82@yahoo.com Tehran University of Medical Sciences scientific Batool Hossein Rashidi
Infertility Clinic, Vali Asr Hospital, ImamKhomeini Hospital Complex, Keshavarz Blvd.,
Tehran Iran (Islamic Republic of) 14194 +98 21 6693 9320 bhrashidi@gmail.com Tehran University of Medical Sciences Iran (Islamic Republic of) Infertile patients candidates for IVF AMH greater than 1 ng / ml First or second IVF cycle The presence of both ovaries Age less than 40 years 20 years 40 years Female Smoking Presence of uterine anomalies Adrenal insufficiency or uncontrolled thyroid Endometriosis grade 3 or More Couples chromosomal disorder Underlying disorder that can lead to ovulatory dysfunction Repeated failure of IVF N97 Female infertility Treatment - Drugs Treatment - Drugs Intervention group: Group A (study group): On the second day of the menstrual cycle, all patients undergo vaginal sonography, and in the absence of follicles greater than 10 mm, the treatment cycle begins. Patients receive oral progesterone or dydrogesterone (Duphaston, 20 mg daily, oral). Six days after the start of treatment, vaginal sonography will be performed. At the same time as starting dydrogesterone (2-3 cycles a day), hMG (225-150 units injected daily) is prescribed. In case of appearance, 2 follicles of 18 mm and 3 follicles of 14-15 mm in ultrasound, for the trigger, decapeptide, will be administered at 0.2 cc. It is worth mentioning that taking dydrogesterone is stopped on the trigger day. Control group: Group B (control): hMG 225-150 injectable units daily) received in 2-3 cycles of menstruation and after administration of hMG, when the follicle reached 13 mm, the Cetrotide antagonist (GnRh, 0.25 mg), It is injected subcutaneously every 24 hours. In case of appearance, 2 follicles of 18 mm and 3 follicles in 14-15 mm in ultrasound, for a trigger, decapeptide, will be prescribed to 0.2 cc. And the antagonist (steroid) injection stops. 36-39 hours after decapeptide injection, ovule collection (OPU, Ovum Pick up) will be done in both groups. n (OPU, Ovum Pick up) will be done in both groups. The ovum obtained is categorized in terms of growth by the embryologist. And 2-3 days after the ICSI, embryos are graded by the number of cells and fragmentation by the specialist. In the next cycle, then in each patient, 2 embryos will be transmitted from the best embryos of good quality (embryos with high blastomeres and without fragmentation) and the embryo transfer will be carried out by one person from the infertility fellowship without knowledge of the patient groups. Number of mature oocyte. Timepoint: Two weeks after treatment. Method of measurement: Vaginal sonography. LH surge. Timepoint: Two weeks after treatment. Method of measurement: Blood test. Tehran University of Medical Sciences Approved 2019-02-19 Ethics committee of Tehran University of Medical Sciences Tehran University of Medical Sciences, Sixth Floor, Quds Building, Keshavarz Blvd Tehran Tehran Iran (Islamic Republic of)