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IRCT20190112042329N1 IRCT 2019-03-03 Mashhad University of Medical Sciences Effect of intracoronary adenosine in patients with acute myocardial infarction A clinical trial on the effectiveness of intracoronary adenosine for the prevention of no-reflow phenomenon in patients with acute myocardial infarction 2019-03-21 anticipated 126 Complete https://irct.ir/trial/37673 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Totally 126 patients with acute myocardial infarction at the Department of Cardiology in Ghaem Hospital, Mashhad, Iran, were chosen. The participants were allocated into groups of intervention and control using the table of random numbers based on computer programs, Blinding description: Patients with acute myocardial infarction at the Department of Cardiology, Ghaem Hospital, Mashhad, Iran, were chosen. In this double-blind study, the clinical care and data collector were blind to group assignment and the type of treatment. 2-3 Acute myocardial infarction. Intervention 1: Control group: the control group will receive 3 mcg adenosine in 50 cc normal saline. Intervention 2: Intervention group: the low dose intervention group will receive 120 mcg adenosine for involvement of right coronary artery and 240 mcg adenosine for involvement of left coronary artery. Intervention 3: Intervention group: the high dose intervention group will receive 240 mcg adenosine for involvement of right coronary artery and 480 mcg adenosine for involvement of left coronary artery. Yes - There is a plan to make this available What will be shared: Information on the main outcome or the like can be shared When: 6 months after printing results To whom: Our data will only be available to researchers working at science centers and universities. Conditions: Our data will be available for scholars working at science centers and universities Where to obtain: Mustafa Baburian provides the data analysis to the applicants via email: babourianm941@mums.ac.ir How to obtain: Applicants can respond to the email of the respondent and receive a response within a week. Comments:
public Mustafa Baburian
Ghaem Hospital, Ahmadabad Street, Dr. Ali Shariati Square
Mashhad Iran (Islamic Republic of) 9176699199 +98 51 3840 0000 babourianm941@mums.ac.ir Mashhad University of Medical Sciences scientific Mustafa Baburian
Ghaem Hospital, Ahmadabad Street, Dr. Ali Shariati Square
Mashhad Iran (Islamic Republic of) 9176699199 +98 51 3840 0000 babourianm941@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Age higher than 20 years An elapse of 12 hours form the primary diagnosis 20 years no limit Both Having chronic obstructive pulmonary disease, asthma, less than 90 mm Hg systolic blood pressure, cardiac arrhythmia, sick sinus syndrome and neuropathy Candidates for coronary artery bypass grafts Using other medicines, such as verapamil I21 Acute myocardial infarction Treatment - Drugs Treatment - Drugs Treatment - Drugs Control group: the control group will receive 3 mcg adenosine in 50 cc normal saline. Intervention group: the low dose intervention group will receive 120 mcg adenosine for involvement of right coronary artery and 240 mcg adenosine for involvement of left coronary artery. Intervention group: the high dose intervention group will receive 240 mcg adenosine for involvement of right coronary artery and 480 mcg adenosine for involvement of left coronary artery. Major adverse cardiovascular events (i.e., mortality, second myocardial infarction, and stroke during admission). Timepoint: Before and 24 hours after the intervention. Method of measurement: Echocardiography. Ejection fraction of ventricular. Timepoint: Before and 24 hours after the intervention. Method of measurement: Echocardiography. The reduction of ST-segment. Timepoint: Before and 24 hours after the intervention. Method of measurement: Electrocardiogram (ECG). Thrombolysis in myocardial infarction flow. Timepoint: Before and 24 hours after the intervention. Method of measurement: TIMI flow grading. Mashhad University of Medical Sciences Approved 2018-10-16 Ethics Committee of Mashhad University of Medical Sciences Vice Chancellor for Research, Mashhad University of Medical Sciences, Ghoreishi building, Daneshgah Street Mashhad Razavi Khorasan Iran (Islamic Republic of)