IRCT20190222042803N1 IRCT 2019-03-10 Ahvaz University of Medical Sciences The Effect of Fibrinogen Injection on Bleeding in Total Knee Arthroplasty The Effect of Fibrinogen Injection on Bleeding in Total Knee Arthroplasty 2019-02-20 anticipated 58 Complete https://irct.ir/trial/37747 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: Individuals are randomly divided into two groups based on randomized block randomization method. Randomized blocks are used for this purpose. A random sample based on this method from Sealedenvelope.com has been extracted, Blinding description: Considering that after dissolving fibrinogen in normal saline, no difference in color compared with normal saline solution, it can be said that the patient, surgeon and data analyzer do not have any information on how to place patients in the groups. 3 Total Knee Arthroplasty. Intervention 1: Intervention group: Local injection of 500 mg of fibrinogen dissolved powder manufactured by CSL Behring USA in 10 ml of normal saline in the knee joint 2 minutes before opening tourniquet. Intervention 2: Control group: Local injection of 10 ml normal saline in the knee joint 2 minutes before opening tourniquet. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information