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IRCT20160422027520N10 IRCT 2019-02-27 Tabriz University of Medical Sciences Treatment of chronic knee osteoarthritis with platelet lysis and platelet-rich plasma The effects of platelet lysate therapy and platelet-rich plasma on chronic knee osteoarthritis 2019-02-09 anticipated 25 Complete https://irct.ir/trial/37850 interventional Randomization: Not randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 3 Knee Osteoarthritis. Intervention group: Patients with knee arthritis receiving platelet lysate and platelet-rich plasma. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information
public Mehdi Yousefi
Tabriz University of Medical Sciences, Golgasht Avenue,Tabriz, Iran
Tabriz Iran (Islamic Republic of) 5166614766 +98 41 3336 4665 yousefime@tbzmed.ac.ir Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran scientific Mehdi Yousefi
Tabriz University of Medical Sciences, Golgasht Avenue,Tabriz, Iran
Tabriz Iran (Islamic Republic of) 5166614766 +98 41 3336 4665 yousefime@tbzmed.ac.ir Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Iran (Islamic Republic of) Men and women between the ages of 18 and 75 with OA diagnosis based on the American College of Rheumatology Analog scale of knee pain (VAS) equal to or greater than 2.5 People with at least 4 months of history of pain or swelling in one or both knees Radiological classification scale Kellgren-Lawrence 1 or 2 The availability of individual during the study period BMI Between 20 and 35 18 years 75 years Both People under the age of 18 and over 75 years Pregnant women or women who are breastfeeding People with malignancy,People with severe heart disease, uncontrolled diabetes mellitus, rheumatoid arthritis, hemorrhagic diseases, history of anemia, arthritis, fibromyalgia and chronic fatigue syndrome Those linked to acetaminophen or Vicodin or a history of drug misuse History of cortisone injections in the last 6 weeks The use of non-steroidal anti-inflammatory drugs 1 week ago Having hemoglobin less than 11 g / dl and platelet count less than 150000 / mμ The use of inhibitors of platelet aggregation and anti-coagulation such as heparin History of knee surgery in the last 3 months Extraordinary deformation (varus >5ᵒ, valgus >5ᵒ) M15.4 Erosive (osteo)arthritis Treatment - Other Intervention group: Patients with knee arthritis receiving platelet lysate and platelet-rich plasma Determining knee pain by VAS in all phases of clinical trial. Timepoint: 1 and 6 months after the first injection. Method of measurement: Questionnaire (Visual Analogue Scale). Determination of knee function by Western Ontario and McMaster Universities Osteoarthritis Index in all phases of clinical trial. Timepoint: 1 and 6 months after the first injection. Method of measurement: Questionnaire (Western Ontario and McMaster Universities Osteoarthritis Index). Determine the range of knee motion by manual joiniometry in all phases of clinical trial. Timepoint: 1 and 6 months after the first injection. Method of measurement: Range of motion (Degree). Measurement of growth factors in platelet lysate and Platelet-rich plasma. Timepoint: 1 and 6 months after the first injection. Method of measurement: Elisa. Determine the thickness of the knee cartilage. Timepoint: 6 months after the first injection. Method of measurement: MRI. Tabriz University of Medical Sciences Approved 2019-02-04 Ethics committee of Tabriz University of Medical Sciences Tabriz University of Medical Sciences , Daneshghah st, Tabriz, Tabriz East Azarbaijan Iran (Islamic Republic of)