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IRCT20190201042577N1 IRCT 2019-03-07 Mashhad University of Medical Sciences The therapeutic effect of Sildenafil Citrate on maternal and fetal outcomes of pregnancies associated with severe preeclampsia The therapeutic effect of Sildenafil Citrate on maternal and fetal outcomes of pregnancies associated with severe preeclampsia 2019-01-19 anticipated 64 Complete https://irct.ir/trial/37889 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple randomization method, individual unit; using a packet packet, Blinding description: Individuals entered into the study are randomly and triple blind divided into two groups by closed packets. The original drug and placebo were named by someone other than the therapist and researcher with the same shape and color as the first drug and the second drug, and each drug was given two groups. Data are analyzed by a statistician who is not aware of the type of medication. 3 Severe Preeclampsia. Intervention 1: Intervention group: receive sildenafil tablets 25 mg every 8 hours. Intervention 2: Control group: receive a tablet of the same color and shape as the sildenafil tablet every 8 hours. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information.
public Azadeh Kamkar
No. 406, Sayed Razi 48 Ave.
Mashhad Iran (Islamic Republic of) 9188737813 +98 51 3611 1357 Kamkara951@mums.ac.ir Mashhad University of Medical Sciences scientific Azadeh Kamkar
No. 406, Sayed Razi 48 Ave.
Mashhad Iran (Islamic Republic of) 9188737813 +98 51 3611 1357 kamkara951@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Pregnant women with single pregnancy with gestational age 24 to 34 weeks Ladies 18 to 50 years old Patients with the diagnosis of severe preeclampsia (systolic blood pressure greater than 160 and diastolic blood pressure greater than 110 in two times with a minimum measurement time of 4 hours and proteinuria greater than 300 mg in 24 hours) indicating an expected treatment. 18 years 50 years Female O14.1 Severe pre-eclampsia Treatment - Drugs Placebo Intervention group: receive sildenafil tablets 25 mg every 8 hours. Control group: receive a tablet of the same color and shape as the sildenafil tablet every 8 hours. The mean of the pregnancy period since the diagnosis of severe preeclampsia until the end of pregnancy. Timepoint: since the diagnosis of severe preeclampsia until the end of pregnancy. Method of measurement: day. Mean maternal blood pressure. Timepoint: Every four hours. Method of measurement: mercury Barometer. Newborn birth weight. Timepoint: at birth. Method of measurement: scaler. Mashhad University of Medical Sciences Approved 2019-01-11 Ethics committee of mashhad University of Medical Sciences Ferdowsi University, Faculty of Medicine mashhad Razavi Khorasan Iran (Islamic Republic of)