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IRCT20190302042885N1 IRCT 2020-04-20 Alborz Univesity of Medical Sience omega3 in depression Comparison of the efficacy of omega-3 as an adjunctive therapy of sertraline and venlafaxine in improving symptoms of major depressive disorder : A Double-blind , placebo controlled trial 2019-03-21 anticipated 64 Complete https://irct.ir/trial/37956 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: After completing the course of treatment and recording the results, matching the delivery codes and the patient's specific code is determined by what treatment the patient received, Blinding description: Patients will be referred to a designated pharmacy after an examination by a psychiatrist and will receive information and receive a specific code, and will be randomized by the provider of the medication, placebo or pills containing omega-3s. After completing the course of treatment and recording the results, matching the delivery codes and the patient's specific code is determined by what treatment the patient received. The patient and psychiatrist are not on the verge of being given a placebo or an effective pill. 3 Major Depression. Intervention 1: Intervention group: 50 mg Sertraline daily plus two grams of Omega 3 daily. Intervention 2: Intervention group: 75 mg of venlafaxine daily plus two grams of omega 3 daily. Intervention 3: Control group:50 mg sertraline daily with placebo. Intervention 4: Control group: 75 mg daily venlafaxine with placebo. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is The timing of the completion of information for publication is unclear
public Mohammad Ahadi Fard Moghadam
Alborz university of medical science,Boo Ali street,karaj
Karaj Iran (Islamic Republic of) 1234567895 +98 26 3677 3900 mohammadafm72@gmail.com Alborz Univesity of Medical Science scientific Mohammad Ahadi Fard Moghadam
Alborz university of medical sience,Boo Ali street,karaj
Karaj Iran (Islamic Republic of) 1234567895 +98 26 3677 3900 mohammadafm72@gmail.com Alborz Univesity of Medical science Iran (Islamic Republic of) Having DSM-V diagnostic criteria for major depressive disorder with clinical diagnosis of psychiatrist Earning a score higher than 7 based on Hamilton's Questionnaire (HAM-D) Obtain informed consent from the patient Age between 18 and 60 years There is no psycho-manifestation 18 years 60 years Both Drug abuse and drug abuse other than nicotine and caffeine IQ less than 70 There is another psychiatric disorder in the diagnostic axis one The presence of a medical condition (especially liver disease, cardiovascular disease and hypertension) or significant neurology F32.9 Depression NOSDepressive disorder NOS Treatment - Drugs Treatment - Drugs Placebo Placebo Intervention group: 50 mg Sertraline daily plus two grams of Omega 3 daily Intervention group: 75 mg of venlafaxine daily plus two grams of omega 3 daily Control group:50 mg sertraline daily with placebo Control group: 75 mg daily venlafaxine with placebo Hamilton questionnaire score. Timepoint: Before treatment and 4 weeks after treatment. Method of measurement: Hamilton questionnaire. Alborz Univesity of Medical Sience Approved 2019-01-14 Ethics committee of Alborz University of Medical Sciences Deputy of Research and Technology,Alley Safariyan,45 meters Golshahr,Karaj,Alborz Province Karaj Alborz Iran (Islamic Republic of)