IRCT20190305042935N1 IRCT 2019-03-14 Shahre-kord University of Medical Sciences Effect of acetaminophen prophylaxis on ductus arteriosus closure in premature infants Study the effect of acetaminophen prophylaxis on ductus arteriosus closure in premature infants under 31 weeks 2019-02-20 anticipated 64 Complete https://irct.ir/trial/38088 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Sampling will be done by convenience method and numbers from 1 to 64 will be assigned to infants based on enrollment order. Infants will be randomly allocated to two intervention and control groups using Random Number Generation (RNG) software. Information such as sample size, study population and number of study groups will be recorded in the software. The software will generate two groups of random numbers for intervention (n: 32) and control (n: 32) groups, according to which allocation will be done. 3 Delayed closure of ductus arteriosus. Intervention 1: Intervention group: This group will receive acetaminophen prophylaxis 10 mg/ kg body weight, every 6 hours for 5 days as drops. Intervention 2: Control group: This group will not receive any medical treatment. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information