IRCT20190207042648N1 IRCT 2019-05-22 Mashhad University of Medical Sciences Effect of magnesium sulfate on induced opiate- withdrawal syndrome Effect of magnesium sulfate on induced opiate- withdrawal syndrome 2019-03-21 anticipated 40 Complete https://irct.ir/trial/38113 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The participants will be divided two groups by simple individual randomization method . When a patients referred to ED will be divided into groups by sealed envelops , Blinding description: The precipitants will be blinded about the treatment. Researcher tells them " you will treat by a infusion of MgSO4 or normal saline". The evaluators will be blinded on the groups treatment. Others( researcher, analyzer and person responsible for patient care) know the groups. 3 withdrawal of opiate. Intervention 1: Intervention group: patients with induced opiate withdrawal. they will treated by magnesium sulfate 3gr Iv Infusion in 20 min stat & 10 mg/kg/h Iv Infusion for 3 hours in addition standard therapy. Intervention 2: Control group: patients with induced opiate withdrawal. they receive Tab clonidine 0.2 mg q1h up to 0.8 mg if SBP> 100 mmhg / Amp Diazepam 10 mg q15 min IV slowly up to 30 mg /Amp Apotel 1gr Iv in 200 cc serum N/s in 20 min. No - There is not a plan to make this available Justification or reason for not sharing IPD is security of participants