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IRCT20190308042972N1 IRCT 2019-10-11 Yazd University of Medical Sciences The effect of varenicline on depression in smokers Evaluation ofTherapeutic Effect of Varenicline on Depression among Smokers Methadone Maintaintenance Therapy 2018-01-21 anticipated 60 Complete https://irct.ir/trial/38138 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: By using simple randomized method, individuals were randomly assigned to control and intervention groups. The direction to read random numbers was from the left side. Even numbers were considered for the intervention group and the odd numbers for the control group, Blinding description: The drug was prepared by a pharmacist that did Varenicline and placebo (starch) in the form of similar capsules and divided into two groups A and B. Until the end of the study, the participants, patients under methadone treatment, residence , and statistics counselor were not informed . 2-3 major depressive disorder. Intervention 1: Intervention group: Citalopram tablet was given 20 mg once a day for 6 weeks and Vareniclin tablet (produced by Kowsar Pharmacy Company) 0.5 mg daily for the first three days and then 1 mg tablet daily for 6 weeks. Intervention 2: Control group: Citalopram tablets 20 mg per day and placebo (starch) in the form of capsules was given one day. No - There is not a plan to make this available Justification or reason for not sharing IPD is No more information
public Dr. Ghasem Dastjerdi
Psychiatry Hospital, Shahid Beheshti Blvd,Taft
Yazd Iran (Islamic Republic of) 8915173160 +98 35 3263 2003 ghasemdastjerdi@yahoo.com Yazd University of Medical Sciences scientific Mohammad Talebpoorardakani
Psychiatry Hospital, Shahid Beheshti Blvd,Taft
Yazd Iran (Islamic Republic of) 8951643745 +98 35 3222 1357 m_talebpoor@yahoo.com.au Yazd University of Medical Sciences Iran (Islamic Republic of) Persons in ranged 18 to 60 years old Smokers under methadone maintenance therapy Patients with Major depressive disorder 18 years 60 years Both The patient's desire to withdraw from the study Create a noticeable and persistent drug problem Have a systemic disease Patients with substance use (Based on Self-report) Patients with psychotic disorder Patients with suicidal thoughts The patients under treatment with psychiatric drugs Depression is follow to substance use Depression is associated with medical illness The patient is taking drugs that cause depression F32 Major depressive disorder, single episode Treatment - Drugs Treatment - Drugs Intervention group: Citalopram tablet was given 20 mg once a day for 6 weeks and Vareniclin tablet (produced by Kowsar Pharmacy Company) 0.5 mg daily for the first three days and then 1 mg tablet daily for 6 weeks. Control group: Citalopram tablets 20 mg per day and placebo (starch) in the form of capsules was given one day. Depression Score. Timepoint: First, 3 weeks later, 6 weeks later. Method of measurement: Beck Depression Inventory(I-II). Yazd University of Medical Sciences Approved 2017-09-03 Ethics Committee of Shahid Sadoughi University of Medical Sciences, Yazd Headquarters of the University of Medical Sciences, Bahonar Square, Yazd Yazd Yazd Iran (Islamic Republic of)