IRCT201507073706N26 IRCT 2016-02-03 Vice chancellor for research, Tabriz University of Medical Sciences The effect of saffron syrup on the labor pain intensity, anxiety and duration of labor The effect of saffron syrup on the labor pain intensity, anxiety and duration of labor in primiparous women: a randomized controlled trial 2016-02-01 anticipated 96 Complete https://irct.ir/trial/3816 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 3 Normal labor and delivery. Intervention 1: The first intervention group: 80 to 240 ml syrup (made by Yashil drug company, Aras)containing 750 mg saffron and 200 mg of sugar palms in 240 ml syrup. 80 ml of the syrup will be taken when cervical dilation is around 3 to 4 cm and there are at least 3 uterine contractions in 10 minutes lasting for 45 to 60 seconds. It will be repeated every two hours for maximum three doses considering pain intensity, uterine contraction, and pattern of fetal heart rate. Intervention 2: The second intervention group: 80 to 240 ml syrup (made by Yashil drug company, Aras) containing 750 mg saffron and artificial sugar (Isonalt) in 240 ml syrup. 80 ml of the syrup will be taken when cervical dilation is around 3 to 4 cm and there are at least 3 uterine contractions in 10 minutes lasting for 45 to 60 seconds. It will be repeated every two hours for maximum three doses considering pain intensity, uterine contraction, and pattern of fetal heart rate. Intervention 3: Control group: 80 to 240 ml syrup (made by Yashil drug company, Aras) containing placebo of saffron and artificial sugar (Isonalt) in 240 ml syrup (identical in color, smell and taste with the saffron syrups. 80 ml of the syrup will be taken when cervical dilation is around 3 to 4 cm and there are at least 3 uterine contractions in 10 minutes lasting for 45 to 60 seconds. It will be repeated every two hours for maximum three doses considering pain intensity, uterine contraction, and pattern of fetal heart.